Nonlinear fitting of multi-compartmental data using Hooke and Jeeves direct search method

Abstract

Compartmental modelling refers to modelling the transport of substances in a system consisting of multiple compartments, which is characterized by the transfer rates among the relevant compartments. In a generalized compartmental system, recycling of substances among the compartments is allowed. Compartmental modelling is a generic technique which is needed in many branches of applied physics. The most challenging task is to determine the transfer rates. The present work described the use of the Hooke and Jeeves (HJ) derivative free direct search method in determining the transfer rates to construct a multi-compartmental model with recycling among the compartments. The use of a direct search method ensures the applicability of the model to functions which are not continuous or differentiable. The present model was successfully validated using previously reported experimental data for distribution of trace elements in four compartments in an animal.

Keywords

• compartmental modelling
• hooke and jeeves method
• numerical analysis
• nonlinear fitting
• derivative free method