Harnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancer

Yunjiao Zhang; Rui Sha; Lan Zhang; Wenbin Zhang; Peipei Jin; Weiguo Xu; Jianxun Ding; Jun Lin; Jing Qian; Guangyu Yao; Rui Zhang; Fanchen Luo; Jie Zeng; Jie Cao; Long-ping Wen

doi:10.1038/s41467-018-06529-y

Nature Communications (Oct 2018)

Harnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancer

Yunjiao Zhang,
Rui Sha,
Lan Zhang,
Wenbin Zhang,
Peipei Jin,
Weiguo Xu,
Jianxun Ding,
Jun Lin,
Jing Qian,
Guangyu Yao,
Rui Zhang,
Fanchen Luo,
Jie Zeng,
Jie Cao,
Long-ping Wen

Affiliations

Yunjiao Zhang: Department of Colorectal & Anal Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology
Rui Sha: School of Life Sciences, University of Science and Technology of China
Lan Zhang: Hefei National Laboratory for Physical Sciences at the Microscale, Center of Advanced Nanocatalysis (CAN-USTC) and Department of Chemical Physics, University of Science and Technology of China
Wenbin Zhang: Department of Colorectal & Anal Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology
Peipei Jin: Department of Colorectal & Anal Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology
Weiguo Xu: Key Laboratory of Polymer Ecomaterials, Changchun Institure of Applied Chemistry, Chinese Academy of Sciences
Jianxun Ding: Key Laboratory of Polymer Ecomaterials, Changchun Institure of Applied Chemistry, Chinese Academy of Sciences
Jun Lin: School of Life Sciences, University of Science and Technology of China
Jing Qian: Department of Colorectal & Anal Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology
Guangyu Yao: School of Life Sciences, University of Science and Technology of China
Rui Zhang: Department of Colorectal & Anal Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology
Fanchen Luo: School of Life Sciences, University of Science and Technology of China
Jie Zeng: Hefei National Laboratory for Physical Sciences at the Microscale, Center of Advanced Nanocatalysis (CAN-USTC) and Department of Chemical Physics, University of Science and Technology of China
Jie Cao: Department of Colorectal & Anal Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology
Long-ping Wen: Department of Colorectal & Anal Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology

DOI: https://doi.org/10.1038/s41467-018-06529-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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“Conventional chemotherapy-photothermal therapy combination has limited efficacy in drug resistant cancers. Here they develop Copper-palladium tetrapod nanoparticles to overcome these challenges and show them to work in synergy with autophagy inhibitors to treat drug resistant cancers”

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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