Nature Communications (Oct 2022)
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions
- Yuanpei Li,
- Xiaoniu He,
- Xiao Lu,
- Zhicheng Gong,
- Qing Li,
- Lei Zhang,
- Ronghui Yang,
- Chengyi Wu,
- Jialiang Huang,
- Jiancheng Ding,
- Yaohui He,
- Wen Liu,
- Ceshi Chen,
- Bin Cao,
- Dawang Zhou,
- Yufeng Shi,
- Juxiang Chen,
- Chuangui Wang,
- Shengping Zhang,
- Jian Zhang,
- Jing Ye,
- Han You
Affiliations
- Yuanpei Li
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Xiaoniu He
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Xiao Lu
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Zhicheng Gong
- Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University
- Qing Li
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Lei Zhang
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Ronghui Yang
- Department of Biochemistry and Molecular Biology, Capital Medical University
- Chengyi Wu
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Jialiang Huang
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Jiancheng Ding
- State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University
- Yaohui He
- State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University
- Wen Liu
- State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University
- Ceshi Chen
- Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences
- Bin Cao
- Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University
- Dawang Zhou
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Yufeng Shi
- Tongji University Cancer Center, Shanghai Tenth People’s Hospital of Tongji University, School of Medicine, Tongji University
- Juxiang Chen
- Department of Neurosurgery, Shanghai Changhai Hospital, Naval Medical University
- Chuangui Wang
- The Biomedical Translational Research Institute, School of Life Sciences, Shandong University of Technology
- Shengping Zhang
- Translational Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Jian Zhang
- The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University
- Jing Ye
- Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University
- Han You
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- DOI
- https://doi.org/10.1038/s41467-022-34209-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 23
Abstract
METTL3 catalyzes mRNA m6A deposition. The authors identify an acetylation-mediated regulation of METTL3 subcellular localization and compartment-specific functions, a process that is fine-tuned by anti-inflammatory and pro-inflammatory signals, which ultimately determine breast cancer metastasis.
