Frontiers in Pharmacology (Nov 2022)
Ferroptosis: A new insight for treatment of acute kidney injury
- Shiyang Li,
- Shiyang Li,
- Shiyang Li,
- Shiyang Li,
- Rui Wang,
- Rui Wang,
- Rui Wang,
- Rui Wang,
- Yixue Wang,
- Yixue Wang,
- Yixue Wang,
- Yixue Wang,
- Yong Liu,
- Yong Liu,
- Yong Liu,
- Yong Liu,
- Yingjin Qiao,
- Peipei Li,
- Peipei Li,
- Peipei Li,
- Peipei Li,
- Jingfang Chen,
- Jingfang Chen,
- Jingfang Chen,
- Jingfang Chen,
- Shaokang Pan,
- Shaokang Pan,
- Shaokang Pan,
- Shaokang Pan,
- Qi Feng,
- Qi Feng,
- Qi Feng,
- Qi Feng,
- Zhangsuo Liu,
- Zhangsuo Liu,
- Zhangsuo Liu,
- Zhangsuo Liu,
- Dongwei Liu,
- Dongwei Liu,
- Dongwei Liu,
- Dongwei Liu
Affiliations
- Shiyang Li
- Traditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Shiyang Li
- Research Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Shiyang Li
- Henan Province Research Center for Kidney Disease, Zhengzhou, China
- Shiyang Li
- Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, China
- Rui Wang
- Traditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Rui Wang
- Research Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Rui Wang
- Henan Province Research Center for Kidney Disease, Zhengzhou, China
- Rui Wang
- Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, China
- Yixue Wang
- Traditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yixue Wang
- Research Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Yixue Wang
- Henan Province Research Center for Kidney Disease, Zhengzhou, China
- Yixue Wang
- Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, China
- Yong Liu
- Traditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yong Liu
- Research Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Yong Liu
- Henan Province Research Center for Kidney Disease, Zhengzhou, China
- Yong Liu
- Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, China
- Yingjin Qiao
- Blood Purification Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Peipei Li
- Traditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Peipei Li
- Research Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Peipei Li
- Henan Province Research Center for Kidney Disease, Zhengzhou, China
- Peipei Li
- Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, China
- Jingfang Chen
- Traditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Jingfang Chen
- Research Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Jingfang Chen
- Henan Province Research Center for Kidney Disease, Zhengzhou, China
- Jingfang Chen
- Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, China
- Shaokang Pan
- Traditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Shaokang Pan
- Research Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Shaokang Pan
- Henan Province Research Center for Kidney Disease, Zhengzhou, China
- Shaokang Pan
- Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, China
- Qi Feng
- Traditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Qi Feng
- Research Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Qi Feng
- Henan Province Research Center for Kidney Disease, Zhengzhou, China
- Qi Feng
- Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, China
- Zhangsuo Liu
- Traditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Zhangsuo Liu
- Research Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Zhangsuo Liu
- Henan Province Research Center for Kidney Disease, Zhengzhou, China
- Zhangsuo Liu
- Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, China
- Dongwei Liu
- Traditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Dongwei Liu
- Research Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Dongwei Liu
- Henan Province Research Center for Kidney Disease, Zhengzhou, China
- Dongwei Liu
- Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, China
- DOI
- https://doi.org/10.3389/fphar.2022.1065867
- Journal volume & issue
-
Vol. 13
Abstract
Acute kidney injury (AKI), one of the most prevalent clinical diseases with a high incidence rate worldwide, is characterized by a rapid deterioration of renal function and further triggers the accumulation of metabolic waste and toxins, leading to complications and dysfunction of other organs. Multiple pathogenic factors, such as rhabdomyolysis, infection, nephrotoxic medications, and ischemia-reperfusion injury, contribute to the onset and progression of AKI. However, the detailed mechanism remains unclear. Ferroptosis, a recently identified mechanism of nonapoptotic cell death, is iron-dependent and caused by lipid peroxide accumulation in cells. A variety of studies have demonstrated that ferroptosis plays a significant role in AKI development, in contrast to other forms of cell death, such as apoptosis, necroptosis, and pyroptosis. In this review, we systemically summarized the definition, primary biochemical mechanisms, key regulators and associated pharmacological research progress of ferroptosis in AKI. We further discussed its therapeutic potential for the prevention of AKI, in the hope of providing a useful reference for further basic and clinical studies.
Keywords
