Nature Communications (Jun 2020)
Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality
- Kylie M. Quinn,
- Tabinda Hussain,
- Felix Kraus,
- Luke E. Formosa,
- Wai K. Lam,
- Michael J. Dagley,
- Eleanor C. Saunders,
- Lisa M. Assmus,
- Erica Wynne-Jones,
- Liyen Loh,
- Carolien E. van de Sandt,
- Lucy Cooper,
- Kim L. Good-Jacobson,
- Katherine Kedzierska,
- Laura K. Mackay,
- Malcolm J. McConville,
- Georg Ramm,
- Michael T. Ryan,
- Nicole L. La Gruta
Affiliations
- Kylie M. Quinn
- Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
- Tabinda Hussain
- Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
- Felix Kraus
- Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
- Luke E. Formosa
- Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
- Wai K. Lam
- Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
- Michael J. Dagley
- Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne
- Eleanor C. Saunders
- Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne
- Lisa M. Assmus
- Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
- Erica Wynne-Jones
- Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity
- Liyen Loh
- Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity
- Carolien E. van de Sandt
- Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity
- Lucy Cooper
- Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
- Kim L. Good-Jacobson
- Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
- Katherine Kedzierska
- Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity
- Laura K. Mackay
- Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity
- Malcolm J. McConville
- Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne
- Georg Ramm
- Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne
- Michael T. Ryan
- Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
- Nicole L. La Gruta
- Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
- DOI
- https://doi.org/10.1038/s41467-020-16633-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Fatty acid oxidation (FAO) is thought to contribute to high spare respiratory capacity (SRC), which in turn affects CD8+ T cell function. Here, the authors show that ex vivo virtual memory T cells (and not antigen experienced memory T cells) have high SRC, a metabolic state that it is affected by ageing and IL-15 signalling and not directly by FAO.
