Communications Biology (Aug 2022)
Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis
- Sanni E. Ruotsalainen,
- Ida Surakka,
- Nina Mars,
- Juha Karjalainen,
- Mitja Kurki,
- Masahiro Kanai,
- Kristi Krebs,
- Sarah Graham,
- Pashupati P. Mishra,
- Binisha H. Mishra,
- Juha Sinisalo,
- Priit Palta,
- Terho Lehtimäki,
- Olli Raitakari,
- Estonian Biobank Research Team,
- Lili Milani,
- The Biobank Japan Project,
- Yukinori Okada,
- FinnGen,
- Aarno Palotie,
- Elisabeth Widen,
- Mark J. Daly,
- Samuli Ripatti
Affiliations
- Sanni E. Ruotsalainen
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Ida Surakka
- Department of Internal Medicine, University of Michigan
- Nina Mars
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Juha Karjalainen
- The Broad Institute of MIT and Harvard
- Mitja Kurki
- The Broad Institute of MIT and Harvard
- Masahiro Kanai
- The Broad Institute of MIT and Harvard
- Kristi Krebs
- Estonian Genome Centre, Institute of Genomics, University of Tartu
- Sarah Graham
- Department of Internal Medicine, University of Michigan
- Pashupati P. Mishra
- Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University
- Binisha H. Mishra
- Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University
- Juha Sinisalo
- Heart and Lung Center, Helsinki University Hospital and Helsinki University
- Priit Palta
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Terho Lehtimäki
- Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University
- Olli Raitakari
- Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
- Estonian Biobank Research Team
- Lili Milani
- Estonian Genome Centre, Institute of Genomics, University of Tartu
- The Biobank Japan Project
- Yukinori Okada
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- FinnGen
- Aarno Palotie
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Elisabeth Widen
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Mark J. Daly
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Samuli Ripatti
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- DOI
- https://doi.org/10.1038/s42003-022-03552-0
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 16
Abstract
A genome-wide association study identifies MFGE8 as protective against coronary atherosclerosis in European and East Asian populations.
