Function-adaptive clustered nanoparticles reverse Streptococcus mutans dental biofilm and maintain microbiota balance

Fatemeh Ostadhossein; Parikshit Moitra; Esra Altun; Debapriya Dutta; Dinabandhu Sar; Indu Tripathi; Shih-Hsuan Hsiao; Valeriya Kravchuk; Shuming Nie; Dipanjan Pan

doi:10.1038/s42003-021-02372-y

Communications Biology (Jul 2021)

Function-adaptive clustered nanoparticles reverse Streptococcus mutans dental biofilm and maintain microbiota balance

Fatemeh Ostadhossein,
Parikshit Moitra,
Esra Altun,
Debapriya Dutta,
Dinabandhu Sar,
Indu Tripathi,
Shih-Hsuan Hsiao,
Valeriya Kravchuk,
Shuming Nie,
Dipanjan Pan

Affiliations

Fatemeh Ostadhossein: Departments of Bioengineering, Beckman Institute, University of Illinois at Urbana-Champaign, Mills Breast Cancer Institute, and Carle Foundation Hospital
Parikshit Moitra: Department of Pediatrics, Center for Blood Oxygen Transport and Hemostasis, Health Sciences Facility III, University of Maryland Baltimore School of Medicine
Esra Altun: Departments of Bioengineering, Beckman Institute, University of Illinois at Urbana-Champaign, Mills Breast Cancer Institute, and Carle Foundation Hospital
Debapriya Dutta: Departments of Bioengineering, Beckman Institute, University of Illinois at Urbana-Champaign, Mills Breast Cancer Institute, and Carle Foundation Hospital
Dinabandhu Sar: Departments of Bioengineering, Beckman Institute, University of Illinois at Urbana-Champaign, Mills Breast Cancer Institute, and Carle Foundation Hospital
Indu Tripathi: Departments of Bioengineering, Beckman Institute, University of Illinois at Urbana-Champaign, Mills Breast Cancer Institute, and Carle Foundation Hospital
Shih-Hsuan Hsiao: Veterinary Diagnostic Laboratory, University of Illinois at Urbana-Champaign
Valeriya Kravchuk: Departments of Bioengineering, Beckman Institute, University of Illinois at Urbana-Champaign, Mills Breast Cancer Institute, and Carle Foundation Hospital
Shuming Nie: Departments of Bioengineering, Carle Illinois College of Medicine, Beckman Institute, Department of Chemistry, Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign
Dipanjan Pan: Departments of Bioengineering, Beckman Institute, University of Illinois at Urbana-Champaign, Mills Breast Cancer Institute, and Carle Foundation Hospital

DOI: https://doi.org/10.1038/s42003-021-02372-y
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 16

Abstract

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Ostadhossein et al. propose an antibiotic-free strategy to disrupt the biofilm by utilizing nanoparticles designed to function in the acidic environment of the biofilms. Phophonium ions functionalised carbon dot nanoclusters in a pH-sensitive polymer shell display dental biofilm inhibition without disrupting the ecological balance of the oral cavity.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal