International Journal of Molecular Sciences (Nov 2020)

Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia

  • Antonio Martinez-Lopez,
  • Trinidad Montero-Vilchez,
  • Álvaro Sierra-Sánchez,
  • Alejandro Molina-Leyva,
  • Salvador Arias-Santiago

Journal volume & issue
Vol. 21, no. 21
p. 8390


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Alopecia is a challenging condition for both physicians and patients. Several topical, intralesional, oral, and surgical treatments have been developed in recent decades, but some of those therapies only provide partial improvement. Advanced medical therapies are medical products based on genes, cells, and/or tissue engineering products that have properties in regenerating, repairing, or replacing human tissue. In recent years, numerous applications have been described for advanced medical therapies. With this background, those therapies may have a role in the treatment of various types of alopecia such as alopecia areata and androgenic alopecia. The aim of this review is to provide dermatologists an overview of the different advanced medical therapies that have been applied in the treatment of alopecia, by reviewing clinical and basic research studies as well as ongoing clinical trials.