Nature Communications (Dec 2020)

MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression

  • Kung-Chi Chang,
  • Sarah D. Diermeier,
  • Allen T. Yu,
  • Lily D. Brine,
  • Suzanne Russo,
  • Sonam Bhatia,
  • Habeeb Alsudani,
  • Karen Kostroff,
  • Tawfiqul Bhuiya,
  • Edi Brogi,
  • Darryl J. Pappin,
  • C. Frank Bennett,
  • Frank Rigo,
  • David L. Spector

DOI
https://doi.org/10.1038/s41467-020-20207-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 19

Abstract

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A group of long non-coding RNAs (lncRNAs), Mammary Tumor Associated RNA s 1-30 (MaTARs 1-30), are differentially expressed between mammary tumor cells and normal mammary epithelial cells. Here the authors report that MaTAR25 plays a role in breast cancer cell proliferation, migration and invasion by regulating the expression of the Tensin1 gene in trans.