The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain

Abstract

The methylation of Histone 3 at Lysine 36 (H3K36) has been implicated in the regulation of transcription and coupled processes such as mRNA splicing. Here the authors show that the histone methyltransferase SETD2 interacts with hnRNP L to mediate the crosstalk between the transcription and splicing machineries.