PLoS ONE (Jan 2019)

Effects of dietary intake and nutritional status on cerebral oxygenation in patients with chronic kidney disease not undergoing dialysis: A cross-sectional study.

  • Susumu Ookawara,
  • Yoshio Kaku,
  • Kiyonori Ito,
  • Kanako Kizukuri,
  • Aiko Namikawa,
  • Shinobu Nakahara,
  • Yuko Horiuchi,
  • Nagisa Inose,
  • Mayako Miyahara,
  • Michiko Shiina,
  • Saori Minato,
  • Mitsutoshi Shindo,
  • Haruhisa Miyazawa,
  • Keiji Hirai,
  • Taro Hoshino,
  • Miho Murakoshi,
  • Kaoru Tabei,
  • Yoshiyuki Morishita

DOI
https://doi.org/10.1371/journal.pone.0223605
Journal volume & issue
Vol. 14, no. 10
p. e0223605

Abstract

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BackgroundDietary management is highly important for the maintenance of renal function in patients with chronic kidney disease (CKD). Cerebral oxygen saturation (rSO2) was reportedly associated with the estimated glomerular filtration rate (eGFR) and cognitive function. However, data concerning the association between cerebral rSO2 and dietary intake of CKD patients is limited.MethodsThis was a single-center observational study. We recruited 67 CKD patients not undergoing dialysis. Cerebral rSO2 was monitored using the INVOS 5100c oxygen saturation monitor. Energy intake was evaluated by dietitians based on 3-day meal records. Daily protein and salt intakes were calculated from 24-h urine collection.ResultsMultivariable regression analysis showed that cerebral rSO2 was independently associated with energy intake (standardized coefficient: 0.370) and serum albumin concentration (standardized coefficient: 0.236) in Model 1 using parameters with p ConclusionsCerebral rSO2 is affected by energy intake, energy/salt index, serum albumin concentration and Hb level. Sufficient energy intake and adequate salt restriction is important to prevent deterioration of cerebral oxygenation, which might contribute to the maintenance of cognitive function in addition to the prevention of renal dysfunction in CKD patients.