Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cross-sectional study
Sfregola Gianfranco,
Sfregola Pamela,
Ruta Federico,
Zendoli Federica,
Musicco Alessandra,
Garzon Simone,
Uccella Stefano,
Etrusco Andrea,
Chiantera Vito,
Terzic Sanja,
Giannini Andrea,
Laganà Antonio Simone
Affiliations
Sfregola Gianfranco
Department of Obstetrics and Gynecology, “Dimiccoli” Hospital, 76121 Barletta, Italy
Sfregola Pamela
Department of Obstetrics and Gynecology, “Dimiccoli” Hospital, 76121 Barletta, Italy
Ruta Federico
Health Agency BAT, General Direction, 76123 Andria, Italy
Zendoli Federica
Department of Obstetrics and Gynecology, Hospital of Bisceglie, 76011 Bisceglie, Italy
Musicco Alessandra
School of Nursing Sciences, University of Foggia, 71122 Foggia, Italy
Garzon Simone
Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37129 Verona, Italy
Uccella Stefano
Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37129 Verona, Italy
Etrusco Andrea
Unit of Gynecologic Oncology, ARNAS “Civico – Di Cristina – Benfratelli”, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90133 Palermo, Italy
Chiantera Vito
Unit of Gynecologic Oncology, ARNAS “Civico – Di Cristina – Benfratelli”, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90133 Palermo, Italy
Terzic Sanja
Department of Medicine, School of Medicine, Nazarbayev University, 010000 Astana, Kazakhstan
Giannini Andrea
Department of Gynecological, Obstetrical and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy
Laganà Antonio Simone
Unit of Gynecologic Oncology, ARNAS “Civico – Di Cristina – Benfratelli”, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90133 Palermo, Italy
The aim of this study was to evaluate the effect of maternal age and body mass index (BMI) on induction of labor with oral misoprostol for premature rupture of membrane (PROM) at term. We have conducted retrospective cross-sectional study, including only term (37 weeks or more of gestation) PROM in healthy nulliparous women with a negative vaginal-rectal swab for group B streptococcus, a single cephalic fetus with normal birthweight, and uneventful pregnancy that were induced after 24 h from PROM. Ninety-one patients were included. According to the multivariate logistic regression, age and BMI odds ratio (OR) for induction success were 0.795 and 0.857, respectively. The study population was divided into two groups based on age (<35 and ≥35 years) and obesity (BMI <30 and ≥30). Older women reported a higher induction failure rate (p < 0.001); longer time to cervical dilation of 6 cm (p = 0.03) and delivery (p < 0.001). Obese women reported a higher induction failure rate (p = 0.01); number of misoprostol doses (p = 0.03), longer time of induction (p = 0.03) to cervical dilatation of 6 cm (p < 0.001), and delivery (p < 0.001); and higher cesarean section (p = 0.012) and episiotomy rate (p = 0.007). In conclusion, maternal age and BMI are two of the main factors that influence oral misoprostol efficacy and affect the failure of induction rate in term PROM.
