Phytomedicine Plus (Feb 2025)
Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunction
Abstract
Background and aim: Erectile dysfunction (ED) is a prevalent condition affecting men worldwide, characterized by the inability to achieve or maintain an erection sufficient for sexual intercourse. Traditional herbal remedies, rooted in cultural practices, have been explored as alternative therapies for ED, and this study focuses on Uvara chemea and Cylicodiscus gabunensis, two plants with reported medicinal properties, as potential alternatives to sildenafil, a standard pharmaceutical for ED. Experimental procedure: Forty male Wistar rats were randomly divided into five groups: control (treated with distilled water), low, medium, and high doses (treated with 61.23, 122.47, and 183.71 mg/kg each of Uvara chemea and Cylicodiscus gabunensis respectively), and a positive control group (treated with sildenafil citrate). The rats were treated for 21 days, and their erectile responses were estimated Results: Significant improvements in erectile responses were observed in rats treated with Uvara chemea and Cylicodiscus gabunensis extracts compared to the control group. When compared to sildenafil citrate, the extracts showed comparable effects in most parameters, with a significant disparity noted in intromission frequency at low and high dosages. Strikingly, there was no significant difference between the extracts treated animals and their counterparts treated with sildenafil citrate. Conclusion: Uvara chemea and Cylicodiscus gabunensis extracts demonstrated potential in ameliorating erectile dysfunction in rats, suggesting their viability as alternative or complementary therapeutic options to sildenafil citrate. Further investigations are necessary to elucidate the underlying mechanisms of action, determine optimal dosages, and evaluate the long-term safety profiles of these herbal extracts for potential human applications.
