HTLV‐1 cell‐free DNA in plasma as a potential biomarker in HTLV‐1 carriers and adult T‐cell leukemia‐lymphoma
Hiroo Katsuya,
Hideaki Nakamura,
Aya Maeda,
Keitaro Ishii,
Toshiaki Nagaie,
Haruhiko Sano,
Haruna Sano,
Hidekazu Itamura,
Sho Okamoto,
Toshihiko Ando,
Toshiki Watanabe,
Kaoru Uchimaru,
Yorifumi Satou,
Eisaburo Sueoka,
Shinya Kimura
Affiliations
Hiroo Katsuya
Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Hideaki Nakamura
Department of Transfusion Medicine Saga University Hospital Saga Japan
Aya Maeda
Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Keitaro Ishii
Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Toshiaki Nagaie
Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Haruhiko Sano
Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Haruna Sano
Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Hidekazu Itamura
Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Sho Okamoto
Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Toshihiko Ando
Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Toshiki Watanabe
Department of Practical Management of Medical Information Graduate School of Medicine St. Marianna University Kawasaki Japan
Kaoru Uchimaru
Laboratories of Tumor Cell Biology Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan
Yorifumi Satou
Division of Genomics and Transcriptomics Joint Research Center for Human Retrovirus Infection Kumamoto University Kumamoto Japan
Eisaburo Sueoka
Department of Clinical Laboratory Medicine Faculty of Medicine Saga University Saga Japan
Shinya Kimura
Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Abstract Viral cell‐free DNA (cfDNA) in plasma has been widely evaluated for detecting cancer and monitoring disease in virus‐associated tumors. We investigated whether the amount of cfDNA of human T‐cell leukemia virus type 1 (HTLV‐1) correlates with disease state in adult T‐cell leukemia‐lymphoma (ATL). HTLV‐1 cfDNA in aggressive ATL was significantly higher than that in indolent ATL and asymptomatic carriers. Notably, patients with lymphoma type represented higher HTLV‐1 cfDNA amount than chronic and smoldering subtypes, though they had no abnormal lymphocytes in the peripheral blood. HTLV‐1 cfDNA can be a universal biomarker that reflects the expansion of ATL clones.
