SMARCA4-deficient tumors in the adrenal gland and small intestines: A rare case report

Akira Kambe, MD; Yayoi Yamamoto, MD, PhD; Chie Hasegawa, MD; Akira Kakiuchi, MD; Daichi Kojima, MD; Ayako Hino, MD, PhD; Ayumi Horikawa, MD, PhD; Tsunehiro Doiuchi, MD; Hiroaki Kurihara, MD, PhD

Radiology Case Reports (Feb 2024)

SMARCA4-deficient tumors in the adrenal gland and small intestines: A rare case report

Akira Kambe, MD,
Yayoi Yamamoto, MD, PhD,
Chie Hasegawa, MD,
Akira Kakiuchi, MD,
Daichi Kojima, MD,
Ayako Hino, MD, PhD,
Ayumi Horikawa, MD, PhD,
Tsunehiro Doiuchi, MD,
Hiroaki Kurihara, MD, PhD

Affiliations

Akira Kambe, MD: Corresponding author.; Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan
Yayoi Yamamoto, MD, PhD: Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan
Chie Hasegawa, MD: Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan
Akira Kakiuchi, MD: Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan
Daichi Kojima, MD: Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan
Ayako Hino, MD, PhD: Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan
Ayumi Horikawa, MD, PhD: Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan
Tsunehiro Doiuchi, MD: Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan
Hiroaki Kurihara, MD, PhD: Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan

Journal volume & issue: Vol. 19, no. 2
pp. 794 – 797

Abstract

Read online

Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UTs) are rare undifferentiated thoracic malignancies with poor prognosis. They predominantly affect young men who are heavy smokers. Recently, the category of SMARCA4-deficiency–related malignancy has been expanded to include extra-thoracic sites, such as the paranasal sinuses, gastrointestinal tract, ovary, and uterus. We report a rare case of SMARCA4-deficient tumors in the adrenal gland and small intestines. SMARCA4-deficient tumors should be included in the differential diagnosis when multiple large masses with heterogeneous contrast effect and strong accumulation are seen in cancers of unknown primary on 18F-fluorodeoxyglucose (FDG) positron emission tomography with computed tomography (PET/CT).

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

About the journal

Abstract

Keywords