Low cost DNA data storage using photolithographic synthesis and advanced information reconstruction and error correction

Philipp L. Antkowiak; Jory Lietard; Mohammad Zalbagi Darestani; Mark M. Somoza; Wendelin J. Stark; Reinhard Heckel; Robert N. Grass

doi:10.1038/s41467-020-19148-3

Nature Communications (Oct 2020)

Low cost DNA data storage using photolithographic synthesis and advanced information reconstruction and error correction

Philipp L. Antkowiak,
Jory Lietard,
Mohammad Zalbagi Darestani,
Mark M. Somoza,
Wendelin J. Stark,
Reinhard Heckel,
Robert N. Grass

Affiliations

Philipp L. Antkowiak: Department of Chemistry and Applied Biosciences, ETH Zürich
Jory Lietard: Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna
Mohammad Zalbagi Darestani: Department of Electrical and Computer Engineering, Rice University
Mark M. Somoza: Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna
Wendelin J. Stark: Department of Chemistry and Applied Biosciences, ETH Zürich
Reinhard Heckel: Department of Electrical and Computer Engineering, Rice University
Robert N. Grass: Department of Chemistry and Applied Biosciences, ETH Zürich

DOI: https://doi.org/10.1038/s41467-020-19148-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

Read online

The current bottleneck for DNA data storage systems is the cost and speed of synthesis. Here, the authors use inexpensive, massively parallel light-directed synthesis and correct for a high error rate with a pipeline of encoding and reconstruction algorithms.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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