Inflammatory Responses of Children with Idiopathic Short Stature to Two Weeks of Inactivity After the One Period of Physical Activity

Abstract

background and aim: physical activity is an important factor in improving the immune system anddecreasing inflammatory agents, which can expand the growth by influencing anabolic and catabolicmediators. This study is being done with the purpose of determine inflammatory responses of children withidiopathic short stature to two weeks inactivity after the one period of physical activity. Materials andMethods: this semi-experimental study was conducted on the population of children attending to endocrineclinic of Atieh hospital of Tehran. 14 idiopathic short stature children (4 girls, 10 boys) were randomlydivided into control and experimental groups. Experimental group performed eight weeks, three sessions eachweek and each session 60 minutes. The intensity of physical activity was 40-60% of HRmax. IL-6, TNF-α andIL-1β were also measured before and after eight weeks of physical activity and after two weeks inactivity.Data were analyzed by kolmogorov-smirnov, independent t test and one-way ANOVA with repeatedmeasures. Results: The result indicate that after eight weeks of physical activity, IL-6 increasedinsignificantly and IL-1β decreased insignificantly(p>0.05). Also, following two weeks of inactivity aftereight weeks, inflammatory cytokines TNF-α , IL-1β decrease and IL-6 increase, but this changes were notsignificant(p>0.05). There was a significant difference between groups in the TNF-α (P=0.005) response aftertwo weeks of inactivity. Conclusion: It seems that some positive effects of physical activity remain even aftertwo weeks of inactivity. Therefore, in order to determine the required time for the inflammatory cytokines tobe increased, researches with workout cycles longer than eight weeks are needed.

Keywords

• idiopathic short stature
• inflammatory cytokines
• inactivity
• physical activity