PTCH1-mutant human cerebellar organoids exhibit altered neural development and recapitulate early medulloblastoma tumorigenesis

• Max J. van Essen,
• Elizabeth J. Apsley,
• Joey Riepsaame,
• Ruijie Xu,
• Paul A. Northcott,
• Sally A. Cowley,
• John Jacob,
• Esther B. E. Becker

Affiliations

Max J. van Essen

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK

Elizabeth J. Apsley

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK

Joey Riepsaame

Genome Engineering Oxford, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE Oxford, UK

Ruijie Xu

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA

Paul A. Northcott

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA

Sally A. Cowley

James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, UK

John Jacob

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK

Esther B. E. Becker

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK