PURINERGIC REGULATION OF BASIC PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES

Abstract

Purinergic signaling has been actively studied over recent years. It happens, due to its involvement in pathogenesis of various diseases and pathologies such as infectious and non-infectious inflammation, tumor growth, graft-versus-host disease, autoimmune disorders, cardiovascular calcification etc. It has been shown that the purinergic system mediates fine tuning of the immune cell populations, like as cytokine and chemokine secretion, elimination of intracellular pathogens and mechanisms of programmed cell death. Novel approaches to therapy and disease prevention are based on studies of appropriate developmental mechanisms, including role of purinergic system in their regulation. This review contains analysis of recent achievements elucidating the role of purinergic regulation in pathogenesis of basic pathological conditions and diseases, as well as trends in development of new therapeutic approaches based on present knowledge.

Keywords

• purinergic regulation
• cd39
• cd73
• atp
• adenosine