Methyldopa electrochemical sensor based on a glassy carbon electrode modified with Cu/TiO2 nanocomposite

Abstract

A Cu/TiO2 nanocomposite modified glassy carbon electrode (Cu/ /TiO2/GCE) was fabricated to detect methyldopa by cyclic voltammetry (CV) and different pulse voltammetry (DPV) methods. Compared with bare GCE, the Cu/TiO2/GCE exhibited excellent electrochemical activity for the oxidation of methyldopa. Using DPV technique, the calibration curves for methyldopa were found linear in the concentration range of 0.5–800.0 μM and the detection limit (S/N = 3) was calculated to be 0.23 μM. Additionally, the prepared electrochemical sensor of Cu/TiO2/GCE demonstrated a practical feasibility in methyldopa tablets and in urine samples analysis.

Keywords

• methyldopa
• Cu/TiO2 nanocomposite
• graphite screen printed electrode
• voltammetry