A scaffold lncRNA shapes the mitosis to meiosis switch

Vedrana Andric; Alicia Nevers; Ditipriya Hazra; Sylvie Auxilien; Alexandra Menant; Marc Graille; Benoit Palancade; Mathieu Rougemaille

doi:10.1038/s41467-021-21032-7

Nature Communications (Feb 2021)

A scaffold lncRNA shapes the mitosis to meiosis switch

Vedrana Andric,
Alicia Nevers,
Ditipriya Hazra,
Sylvie Auxilien,
Alexandra Menant,
Marc Graille,
Benoit Palancade,
Mathieu Rougemaille

Affiliations

Vedrana Andric: Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
Alicia Nevers: Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
Ditipriya Hazra: Laboratoire de Biologie Structurale de la Cellule (BIOC), CNRS, Ecole polytechnique, Institut Polytechnique de Paris
Sylvie Auxilien: Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
Alexandra Menant: Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
Marc Graille: Laboratoire de Biologie Structurale de la Cellule (BIOC), CNRS, Ecole polytechnique, Institut Polytechnique de Paris
Benoit Palancade: Université de Paris, CNRS, Institut Jacques Monod
Mathieu Rougemaille: Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)

DOI: https://doi.org/10.1038/s41467-021-21032-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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In fission yeast, the antagonistic RNA-binding proteins Mmi1 and Mei2 respectively promote and inhibit meiotic mRNA degradation during mitotic growth. Here the authors show that the lncRNA mamRNA scaffolds Mmi1 and Mei2 proteins to enable their mutual controls.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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