Cytochrome P-450 3A4 system in patients with acute myocardial infarction

Abstract

Aim. To investigate CYP 3A4 system functioning and its clinico-laboratory correlations in acute myocardial infarction (AMI).Material and methods. The study included 50 patients hospitalized in the first 24 hours of AMI with ST segment elevation (STE-AMI). Monoethylglycinexylidide (MEGX) test was performed at the hospital admission, at Day 4-5 and Day 14.Results. Baseline MEGX level was significantly higher in non-complicated AMI group (132,1+16,85 ng/ml) than in patients with heart failure (HF) symptoms (31,9+2,02 ng/ml; p<0,001) or healthy volunteers (63,6+14,01 ng/ ml; p<0,001). Phenobarbital administration significantly enhanced CYP 3A4 activity in both AMI groups.Conclusion. In AMI, CYP 3A4 system activity was suppressed among patients with acute HF symptoms. This could be explained by ischemic and congestive liver disturbances. In STE-AMI, pharmacological CYP 3A4 stimulation is possible.

Keywords

• моноэтилглицинэксилидид
• cyp 3a4
• инфаркт миокарда
• сердечная недостаточность
• фенобарбитал