Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model

Christina L. Hutson; Ashley V. Kondas; Mathew R. Mauldin; Jeffrey B. Doty; Irma M. Grossi; Clint N. Morgan; Sharon Dietz Ostergaard; Christine M. Hughes; Yoshinori Nakazawa; Chantal Kling; Brock E. Martin; James A. Ellison; Darin D. Carroll; Nadia F. Gallardo-Romero; Victoria A. Olson

doi:10.1128/mSphere.00927-20

mSphere (Feb 2021)

Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model

Christina L. Hutson,
Ashley V. Kondas,
Mathew R. Mauldin,
Jeffrey B. Doty,
Irma M. Grossi,
Clint N. Morgan,
Sharon Dietz Ostergaard,
Christine M. Hughes,
Yoshinori Nakazawa,
Chantal Kling,
Brock E. Martin,
James A. Ellison,
Darin D. Carroll,
Nadia F. Gallardo-Romero,
Victoria A. Olson

Affiliations

Christina L. Hutson: ORCiD; Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Ashley V. Kondas: Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Mathew R. Mauldin: Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Jeffrey B. Doty: Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Irma M. Grossi: Chimerix, Durham, North Carolina, USA
Clint N. Morgan: Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Sharon Dietz Ostergaard: Animal Resources Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Christine M. Hughes: Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Yoshinori Nakazawa: Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Chantal Kling: Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Brock E. Martin: Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
James A. Ellison: ORCiD; Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Darin D. Carroll: Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Nadia F. Gallardo-Romero: Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Victoria A. Olson: Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

DOI: https://doi.org/10.1128/mSphere.00927-20
Journal volume & issue: Vol. 6, no. 1

Abstract

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Preparedness activities against highly transmissible viruses with high mortality rates have been highlighted during the ongoing coronavirus disease 2019 (COVID-19) pandemic. Smallpox, caused by variola virus (VARV) infection, is highly transmissible, with an estimated 30% mortality.

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

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