mSphere
(Feb 2021)
Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model
Christina L. Hutson,
Ashley V. Kondas,
Mathew R. Mauldin,
Jeffrey B. Doty,
Irma M. Grossi,
Clint N. Morgan,
Sharon Dietz Ostergaard,
Christine M. Hughes,
Yoshinori Nakazawa,
Chantal Kling,
Brock E. Martin,
James A. Ellison,
Darin D. Carroll,
Nadia F. Gallardo-Romero,
Victoria A. Olson
Affiliations
Christina L. Hutson
ORCiD Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Ashley V. Kondas
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Mathew R. Mauldin
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Jeffrey B. Doty
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Irma M. Grossi
Chimerix, Durham, North Carolina, USA
Clint N. Morgan
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Sharon Dietz Ostergaard
Animal Resources Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Christine M. Hughes
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Yoshinori Nakazawa
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Chantal Kling
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Brock E. Martin
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
James A. Ellison
ORCiD Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Darin D. Carroll
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Nadia F. Gallardo-Romero
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Victoria A. Olson
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
DOI
https://doi.org/10.1128/mSphere.00927-20
Journal volume & issue
Vol. 6,
no. 1
Abstract
Read online
Preparedness activities against highly transmissible viruses with high mortality rates have been highlighted during the ongoing coronavirus disease 2019 (COVID-19) pandemic. Smallpox, caused by variola virus (VARV) infection, is highly transmissible, with an estimated 30% mortality.
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