The structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3

Qing Zhang; Deqiang Yao; Bing Rao; Liyan Jian; Yang Chen; Kexin Hu; Ying Xia; Shaobai Li; Yafeng Shen; An Qin; Jie Zhao; Lu Zhou; Ming Lei; Xian-Cheng Jiang; Yu Cao

doi:10.1038/s41467-021-27244-1

Nature Communications (Nov 2021)

The structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3

Qing Zhang,
Deqiang Yao,
Bing Rao,
Liyan Jian,
Yang Chen,
Kexin Hu,
Ying Xia,
Shaobai Li,
Yafeng Shen,
An Qin,
Jie Zhao,
Lu Zhou,
Ming Lei,
Xian-Cheng Jiang,
Yu Cao

Affiliations

Qing Zhang: CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Deqiang Yao: Institute of Precision Medicine, the Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Bing Rao: Institute of Precision Medicine, the Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Liyan Jian: Institute of Precision Medicine, the Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Yang Chen: Institute of Precision Medicine, the Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Kexin Hu: Institute of Precision Medicine, the Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Ying Xia: Institute of Precision Medicine, the Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Shaobai Li: Institute of Precision Medicine, the Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Yafeng Shen: Institute of Precision Medicine, the Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
An Qin: Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Jie Zhao: Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Lu Zhou: Department of Medicinal Chemistry, School of Pharmacy, Fudan University
Ming Lei: Institute of Precision Medicine, the Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Xian-Cheng Jiang: Department of Cell Biology, State University of New York Downstate Health Sciences University
Yu Cao: Institute of Precision Medicine, the Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine

DOI: https://doi.org/10.1038/s41467-021-27244-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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During phosphatidylcholine (PC) remodeling re-acylation is catalyzed by lysophosphatidylcholine acyltransferases (LPCAT). Here, the authors present crystal and cryo-EM structures of chicken LPCAT3 in the apo-, acyl donor-bound and acyl receptor-bound states, and based on the structures and further functional analysis they discuss the mechanism of the enzyme.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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