Ist1 regulates ESCRT-III assembly and function during multivesicular endosome biogenesis in Caenorhabditis elegans embryos

E. B. Frankel; Raakhee Shankar; James J. Moresco; John R. Yates; Niels Volkmann; Anjon Audhya

doi:10.1038/s41467-017-01636-8

Nature Communications (Nov 2017)

Ist1 regulates ESCRT-III assembly and function during multivesicular endosome biogenesis in Caenorhabditis elegans embryos

E. B. Frankel,
Raakhee Shankar,
James J. Moresco,
John R. Yates,
Niels Volkmann,
Anjon Audhya

Affiliations

E. B. Frankel: Department of Biomolecular Chemistry, University of Wisconsin-Madison School of Medicine and Public Health
Raakhee Shankar: Department of Biomolecular Chemistry, University of Wisconsin-Madison School of Medicine and Public Health
James J. Moresco: The Scripps Research Institute, 10550 North Torrey Pines Rd., Department of Chemical Physiology
John R. Yates: The Scripps Research Institute, 10550 North Torrey Pines Rd., Department of Chemical Physiology
Niels Volkmann: Bioinformatics and Structural Biology Program, Sanford-Burnham Medical Research Institute
Anjon Audhya: Department of Biomolecular Chemistry, University of Wisconsin-Madison School of Medicine and Public Health

DOI: https://doi.org/10.1038/s41467-017-01636-8
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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During the oocyte-to-embryo transition in C. elegans, multivesicular endosomes (MVEs) are formed rapidly. Using live imaging and electron microscopy, the authors here show that the ESCRT-III subunit Ist1 is required for normal MVE biogenesis in the early C. elegans embryo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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