Indonesian Journal of Pharmacy (Sep 2015)

IN VITRO ANTIDIABETIC AND IN VIVO ANTIDIARRHEAL ACTIVITY OF Oncoba Spinosa ROOTS

  • Prasanth Kumar M,
  • Suba V,
  • Srinivas Babu P ,
  • Ramireddy B

DOI
https://doi.org/10.14499/indonesianjpharm25iss3pp121
Journal volume & issue
Vol. 26, no. 3
pp. 121 – 128

Abstract

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The different extracts of O.spinosa (Flacourtiaceae) were screened for in-vitro antidiabetic activity. Of all the extracts tested, ethanolic extract showed highest alpha amylase inhibition ranging from 8.64+0.66% to 79.94+0.65% and alpha glucosidase inhibition ranging from 14.12+0.51% to 78.68+0.36% when studied at concentrations 62.5-1000μg/mL. The ethanolic extract was subjected to antidiarrheal activity and diarrheal severity was reduced significantly by 15.81% in 100mg/kg group, 30.45% in 200mg/kg group and 74.37% in 400mg/kg group in castor oil induced diarrhea model. In castor oil induced enteropooling, the extract at doses 200mg/kg and 400mg/kg showed 33.46% and 42.44% inhibition of intestinal accumulation. In the charcoal meal test, the distance travelled by charcoal meal was significantly reduced by the extract at doses 200mg/kg and 400mg/kg (P<0.01). The overall results tend to suggest the antidiabetic and antidiarrheal activities of O. spinosa.

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