Immunity & Ageing (Nov 2022)
The oldest unvaccinated Covid-19 survivors in South America
- Mateus V. de Castro,
- Monize V. R. Silva,
- Michel S. Naslavsky,
- Marilia O. Scliar,
- Kelly Nunes,
- Maria Rita Passos-Bueno,
- Erick C. Castelli,
- Jhosiene Y. Magawa,
- Flávia L. Adami,
- Ana I. S. Moretti,
- Vivian L. de Oliveira,
- Silvia B. Boscardin,
- Edecio Cunha-Neto,
- Jorge Kalil,
- Emmanuelle Jouanguy,
- Paul Bastard,
- Jean-Laurent Casanova,
- Mauricio Quiñones-Vega,
- Patricia Sosa-Acosta,
- Jéssica S. de Guedes,
- Natália P. de Almeida,
- Fábio C. S. Nogueira,
- Gilberto B. Domont,
- Keity S. Santos,
- Mayana Zatz
Affiliations
- Mateus V. de Castro
- Human Genome and Stem Cell Research Center, University of São Paulo
- Monize V. R. Silva
- Human Genome and Stem Cell Research Center, University of São Paulo
- Michel S. Naslavsky
- Human Genome and Stem Cell Research Center, University of São Paulo
- Marilia O. Scliar
- Human Genome and Stem Cell Research Center, University of São Paulo
- Kelly Nunes
- Human Genome and Stem Cell Research Center, University of São Paulo
- Maria Rita Passos-Bueno
- Human Genome and Stem Cell Research Center, University of São Paulo
- Erick C. Castelli
- Department of Pathology, School of Medicine, UNESP - São Paulo State University
- Jhosiene Y. Magawa
- Laboratório de Imunologia, Instituto do Coração (InCor), LIM19, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP)
- Flávia L. Adami
- Laboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo
- Ana I. S. Moretti
- Laboratório de Imunologia, Instituto do Coração (InCor), LIM19, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP)
- Vivian L. de Oliveira
- Laboratório de Imunologia, Instituto do Coração (InCor), LIM19, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP)
- Silvia B. Boscardin
- Laboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo
- Edecio Cunha-Neto
- Instituto de Investigação em Imunologia-Instituto Nacional de Ciências e Tecnologia-iii-INCT
- Jorge Kalil
- Laboratório de Imunologia, Instituto do Coração (InCor), LIM19, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP)
- Emmanuelle Jouanguy
- Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children
- Paul Bastard
- Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children
- Jean-Laurent Casanova
- Imagine Institute, University of Paris
- Mauricio Quiñones-Vega
- Proteomics Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro
- Patricia Sosa-Acosta
- Proteomics Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro
- Jéssica S. de Guedes
- Proteomics Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro
- Natália P. de Almeida
- Proteomics Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro
- Fábio C. S. Nogueira
- Proteomics Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro
- Gilberto B. Domont
- Proteomics Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro
- Keity S. Santos
- Laboratório de Imunologia, Instituto do Coração (InCor), LIM19, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP)
- Mayana Zatz
- Human Genome and Stem Cell Research Center, University of São Paulo
- DOI
- https://doi.org/10.1186/s12979-022-00310-y
- Journal volume & issue
-
Vol. 19,
no. 1
pp. 1 – 9
Abstract
Abstract Background Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated. Results Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN. Conclusion These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity.
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