Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turkss⃞

Uğur Hodoğlugil; Sinan Tanyolaç; David W. Williamson; Yadong Huang; Robert W. Mahley

Journal of Lipid Research (Jan 2006)

Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turkss⃞

Uğur Hodoğlugil,
Sinan Tanyolaç,
David W. Williamson,
Yadong Huang,
Robert W. Mahley

Affiliations

Uğur Hodoğlugil: Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA; Graduate Program in Biological and Medical Informatics, University of California, San Francisco, San Francisco, CA; Department of Pathology, University of California, San Francisco, San Francisco, CA; Department of Medicine, University of California, San Francisco, San Francisco, CA; Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University, Istanbul, Turkey
Sinan Tanyolaç: Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA; Graduate Program in Biological and Medical Informatics, University of California, San Francisco, San Francisco, CA; Department of Pathology, University of California, San Francisco, San Francisco, CA; Department of Medicine, University of California, San Francisco, San Francisco, CA; Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University, Istanbul, Turkey
David W. Williamson: Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA; Graduate Program in Biological and Medical Informatics, University of California, San Francisco, San Francisco, CA; Department of Pathology, University of California, San Francisco, San Francisco, CA; Department of Medicine, University of California, San Francisco, San Francisco, CA; Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University, Istanbul, Turkey
Yadong Huang: Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA; Graduate Program in Biological and Medical Informatics, University of California, San Francisco, San Francisco, CA; Department of Pathology, University of California, San Francisco, San Francisco, CA; Department of Medicine, University of California, San Francisco, San Francisco, CA; Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University, Istanbul, Turkey
Robert W. Mahley: Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA; Graduate Program in Biological and Medical Informatics, University of California, San Francisco, San Francisco, CA; Department of Pathology, University of California, San Francisco, San Francisco, CA; Department of Medicine, University of California, San Francisco, San Francisco, CA; Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University, Istanbul, Turkey

Journal volume & issue: Vol. 47, no. 1
pp. 144 – 153

Abstract

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The apolipoprotein A-V gene (APOA5) plays an important role in determining plasma triglyceride levels. We studied the effects of APOA5 polymorphisms on plasma triglyceride levels in Turks, a population with low levels of HDL cholesterol and a high prevalence of coronary artery disease. We found 15 polymorphisms, three of which were novel. Seven haplotype-tagging single nucleotide polymorphisms (SNPs) were chosen and genotyped in ∼3,000 subjects. The rare alleles of the −1464T>C, −1131T>C, S19W, and 1259T>C SNPs were significantly associated with increased triglyceride levels (19–86 mg/dl; P C polymorphism had no effect by itself but was a marker for the −1131T>C, S19W, and 1259T>C polymorphisms. The −1131T>C and 1259T>C polymorphisms were in a strong but incomplete linkage disequilibrium and appeared to have independent effects. Thus, the APOA5 −1131T>C, S19W, and 1259T>C rare alleles were associated with significant increases in plasma triglyceride levels. At least one of these alleles was present in ∼40% of the Turks. Similar associations were observed for −1131T>C and S19W in white Americans living in San Francisco, California.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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