Nature Communications (Nov 2018)
Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis
- Yunshu Wu,
- Liang Xie,
- Mengyuan Wang,
- Qiuchan Xiong,
- Yuchen Guo,
- Yu Liang,
- Jing Li,
- Rui Sheng,
- Peng Deng,
- Yuan Wang,
- Rixin Zheng,
- Yizhou Jiang,
- Ling Ye,
- Qianming Chen,
- Xuedong Zhou,
- Shuibin Lin,
- Quan Yuan
Affiliations
- Yunshu Wu
- State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- Liang Xie
- State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- Mengyuan Wang
- State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- Qiuchan Xiong
- State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- Yuchen Guo
- State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- Yu Liang
- Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University
- Jing Li
- State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- Rui Sheng
- State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- Peng Deng
- State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- Yuan Wang
- State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- Rixin Zheng
- State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- Yizhou Jiang
- Institute for Advanced Study, Shenzhen University
- Ling Ye
- State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- Qianming Chen
- State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- Xuedong Zhou
- State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- Shuibin Lin
- Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University
- Quan Yuan
- State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- DOI
- https://doi.org/10.1038/s41467-018-06898-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
mRNA modifications have been shown to regulate mammalian development and disease. Here the authors show that the m6A methyltransferase Mettl3 ensures translational efficiency of the mesenchymal stem cell lineage allocator Pth1r, promoting osteogenesis and protecting from osteoporosis.
