Nuclear soluble cGAS senses double-stranded DNA virus infection

Yakun Wu; Kun Song; Wenzhuo Hao; Jack Li; Lingyan Wang; Shitao Li

doi:10.1038/s42003-022-03400-1

Communications Biology (May 2022)

Nuclear soluble cGAS senses double-stranded DNA virus infection

Yakun Wu,
Kun Song,
Wenzhuo Hao,
Jack Li,
Lingyan Wang,
Shitao Li

Affiliations

Yakun Wu: Department of Microbiology and Immunology, Tulane University
Kun Song: Department of Microbiology and Immunology, Tulane University
Wenzhuo Hao: Department of Microbiology and Immunology, Tulane University
Jack Li: Department of Microbiology and Immunology, Tulane University
Lingyan Wang: Department of Microbiology and Immunology, Tulane University
Shitao Li: Department of Microbiology and Immunology, Tulane University

DOI: https://doi.org/10.1038/s42003-022-03400-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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Cellular infection with HSV-1 releases cGAS from the chromatin into the nuclear soluble fraction, leading to viral sensing and a type I interferon host response.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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