N6-Methyladenosine (m6A) Modification in Natural Immune Cell-Mediated Inflammatory Diseases

Yan Teng; Jin Yi; Junnian Chen; Lu Yang

doi:10.1159/000534162

Journal of Innate Immunity (Oct 2023)

N6-Methyladenosine (m6A) Modification in Natural Immune Cell-Mediated Inflammatory Diseases

Yan Teng,
Jin Yi,
Junnian Chen,
Lu Yang

Affiliations

Yan Teng: Institute of Neurology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Jin Yi: Center for Informational Biology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China
Junnian Chen: School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Lu Yang: Institute of Neurology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China

DOI: https://doi.org/10.1159/000534162
Journal volume & issue: Vol. 15, no. 1
pp. 804 – 821

Abstract

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The post-transcriptional N6-methyladenosine (m6A) modification of RNA influences stability, transport, and translation with implications for various physiological and pathological processes. Immune cell development, differentiation, and activation are also thought to be regulated by m6A and affect host defense against pathogens and inflammatory response with impacts on infectious, neoplastic, autoimmune, cardiovascular, hepatic, and osteal diseases. The current review summarizes recent research on m6A in monocyte/macrophages, neutrophils, dendritic cells, natural killer cells, and microglia and gives insights into epigenetic modifications of the immune system and novel therapeutic strategies for immune-related diseases.

Published in Journal of Innate Immunity

ISSN: 1662-811X (Print); 1662-8128 (Online)
Publisher: Karger Publishers
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine
Website: https://www.karger.com/Journal/Home/234234

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