Nature Communications (Feb 2020)
Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis
- Yun Liao,
- Junjie Zhao,
- Katarzyna Bulek,
- Fangqiang Tang,
- Xing Chen,
- Gang Cai,
- Shang Jia,
- Paul L. Fox,
- Emina Huang,
- Theresa T. Pizarro,
- Matthew F. Kalady,
- Mark W. Jackson,
- Shideng Bao,
- Ganes C. Sen,
- George R. Stark,
- Christopher J. Chang,
- Xiaoxia Li
Affiliations
- Yun Liao
- Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic
- Junjie Zhao
- Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic
- Katarzyna Bulek
- Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic
- Fangqiang Tang
- Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic
- Xing Chen
- Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic
- Gang Cai
- Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic
- Shang Jia
- Departments of Chemistry and Molecular and Cell Biology, University of California
- Paul L. Fox
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Emina Huang
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Theresa T. Pizarro
- Department of Pathology, Case Western Reserve University
- Matthew F. Kalady
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Mark W. Jackson
- Department of Pathology, Case Western Reserve University
- Shideng Bao
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Ganes C. Sen
- Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic
- George R. Stark
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Christopher J. Chang
- Departments of Chemistry and Molecular and Cell Biology, University of California
- Xiaoxia Li
- Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic
- DOI
- https://doi.org/10.1038/s41467-020-14698-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
STEAP4 promotes the uptake of copper, and copper is known to be enhanced in cancer tissues. Here, the authors show that STEAP4 is induced by IL17, which is increased in inflamed tissues, consequently the increased copper levels activate NFκB signalling and suppression of apoptosis.
