Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation

Rachel K. Zwick; Michael C. Rudolph; Brett A. Shook; Brandon Holtrup; Eve Roth; Vivian Lei; Alexandra Van Keymeulen; Victoria Seewaldt; Stephanie Kwei; John Wysolmerski; Matthew S. Rodeheffer; Valerie Horsley

doi:10.1038/s41467-018-05911-0

Nature Communications (Sep 2018)

Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation

Rachel K. Zwick,
Michael C. Rudolph,
Brett A. Shook,
Brandon Holtrup,
Eve Roth,
Vivian Lei,
Alexandra Van Keymeulen,
Victoria Seewaldt,
Stephanie Kwei,
John Wysolmerski,
Matthew S. Rodeheffer,
Valerie Horsley

Affiliations

Rachel K. Zwick: Department of Molecular, Cellular and Developmental Biology, Yale University
Michael C. Rudolph: Division of Endocrinology, Metabolism, and Diabetes, University of Colorado
Brett A. Shook: Department of Molecular, Cellular and Developmental Biology, Yale University
Brandon Holtrup: Department of Molecular, Cellular and Developmental Biology, Yale University
Eve Roth: Department of Molecular, Cellular and Developmental Biology, Yale University
Vivian Lei: Department of Molecular, Cellular and Developmental Biology, Yale University
Alexandra Van Keymeulen: WELBIO, Interdisciplinary Research Institute (IRIBHM), Université Libre de Bruxelles (ULB)
Victoria Seewaldt: Department of Population Sciences and Bekman Institute, City of Hope
Stephanie Kwei: Section of Plastic and Reconstructive Surgery, Department of Surgery, Yale University
John Wysolmerski: Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University
Matthew S. Rodeheffer: Department of Molecular, Cellular and Developmental Biology, Yale University
Valerie Horsley: Department of Molecular, Cellular and Developmental Biology, Yale University

DOI: https://doi.org/10.1038/s41467-018-05911-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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During mammary gland involution, the organ undergoes extensive remodeling. Here, the authors explore the role of mammary gland adipose tissue (mgWAT) in this process and demonstrate that adipocyte hypertrophy and lipid trafficking underlie mgWAT expansion and epithelial regression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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