Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Journal of Extracellular Vesicles. 2018;7(1) DOI 10.1080/20013078.2018.1535750

 

Journal Homepage

Journal Title: Journal of Extracellular Vesicles

ISSN: 2001-3078 (Online)

Publisher: Taylor & Francis Group

Society/Institution: International Society for Extracellular Vesicles (ISEV)

LCC Subject Category: Science: Biology (General): Cytology

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS

Clotilde Théry (Institut Curie, INSERM U932, PSL Research University)
Kenneth W Witwer (The Johns Hopkins University School of Medicine)
Elena Aikawa (Brigham and Women’s Hospital)
Maria Jose Alcaraz (University of Valencia, Polytechnic University of Valencia)
Johnathon D Anderson (University of California, Davis)
Ramaroson Andriantsitohaina (INSERM U1063, Université d’Angers, CHU d’Angers)
Anna Antoniou (German Centre for Neurodegenerative Diseases (DZNE))
Tanina Arab (Université de Lille, INSERM, U-1192)
Fabienne Archer (University of Lyon, INRA, EPHE)
Georgia K Atkin-Smith (La Trobe University, La Trobe Institute for Molecular Science)
D Craig Ayre (Atlantic Cancer Research Institute)
Jean-Marie Bach (Université Bretagne Loire, Oniris, INRA, IECM)
Daniel Bachurski (University of Cologne)
Hossein Baharvand (Royan Institute for Stem Cell Biology and Technology, ACECR, Cell Science Research Center)
Leonora Balaj (Massachusetts General Hospital)
Shawn Baldacchino (University of Malta)
Natalie N Bauer (University of South Alabama)
Amy A Baxter (La Trobe University, La Trobe Institute for Molecular Science)
Mary Bebawy (University of Technology Sydney)
Carla Beckham (University of Rochester)
Apolonija Bedina Zavec (National Institute of Chemistry)
Abderrahim Benmoussa (Université Laval, Centre de Recherche du CHU de Québec)
Anna C Berardi (Ospedale Santo Spirito)
Paolo Bergese (CSGI - Research Center for Colloids and Nanoscience)
Ewa Bielska (University of Birmingham, Institute of Microbiology and Infection)
Cherie Blenkiron (University of Auckland)
Sylwia Bobis-Wozowicz (Jagiellonian University)
Eric Boilard (Université Laval, Centre de Recherche du CHU de Québec)
Wilfrid Boireau (UBFC, CNRS, ENSMM, UTBM)
Antonella Bongiovanni (National Research Council (CNR) of Italy)
Francesc E Borràs (Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, REMAR-IVECAT Group)
Steffi Bosch (Université Bretagne Loire, Oniris, INRA, IECM)
Chantal M Boulanger (INSERM UMR-S 970, Paris Cardiovascular Research Center)
Xandra Breakefield (Massachusetts General Hospital and Neuroscience Program, Harvard Medical School)
Andrew M Breglio (Icahn School of Medicine at Mount Sinai)
Meadhbh Á Brennan (Harvard University)
David R Brigstock (Nationwide Children’s Hospital)
Alain Brisson (UMR-CBMN, CNRS-Université de Bordeaux)
Marike LD Broekman (Haaglanden Medical Center)
Jacqueline F Bromberg (Memorial Sloan Kettering Cancer Center)
Paulina Bryl-Górecka (Lund University)
Shilpa Buch (University of Nebraska Medical Center)
Amy H Buck (University of Edinburgh, Institute of Immunology & Infection Research)
Dylan Burger (Kidney Research Centre)
Sara Busatto (Mayo Clinic)
Dominik Buschmann (Technical University of Munich, TUM School of Life Sciences Weihenstephan)
Benedetta Bussolati (University of Torino)
Edit I Buzás (MTA-SE Immuno-Proteogenomics Research Groups)
James Bryan Byrd (University of Michigan)
Giovanni Camussi (University of Torino)
David RF Carter (Oxford Brookes University)
Sarah Caruso (La Trobe University, La Trobe Institute for Molecular Science)
Lawrence W Chamley (University of Auckland)
Yu-Ting Chang (National Taiwan University Hospital)
Chihchen Chen (National Tsing Hua University)
Shuai Chen (Leibniz Institute for Farm Animal Biology (FBN), Institute of Reproductive Biology)
Lesley Cheng (La Trobe University, La Trobe Institute for Molecular Science)
Andrew R Chin (Cedars-Sinai Medical Center)
Aled Clayton (Cardiff University)
Stefano P Clerici (UNICAMP, Institute of Biology)
Alex Cocks (Cardiff University)
Emanuele Cocucci (The Ohio State University, College of Pharmacy)
Robert J Coffey (Vanderbilt University Medical Center, Epithelial Biology Center)
Anabela Cordeiro-da-Silva (University of Porto)
Yvonne Couch (University of Oxford)
Frank AW Coumans (Academic Medical Centre of the University of Amsterdam)
Beth Coyle (The University of Nottingham)
Rossella Crescitelli (University of Gothenburg, Institute of Medicine at Sahlgrenska Academy, Krefting Research Centre)
Miria Ferreira Criado (University of São Paulo, Ribeirão Preto Medical School)
Crislyn D’Souza-Schorey (University of Notre Dame)
Saumya Das (Massachusetts General Hospital)
Amrita Datta Chaudhuri (The Johns Hopkins University School of Medicine)
Paola de Candia (IRCCS MultiMedica)
Eliezer F De Santana (The Sociedade Beneficente Israelita Brasileira Albert Einstein)
Olivier De Wever (Cancer Research Institute Ghent)
Hernando A del Portillo (Institució Catalana de Recerca i Estudis Avançats (ICREA))
Tanguy Demaret (Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC))
Sarah Deville (Universiteit Hasselt)
Andrew Devitt (Aston University)
Bert Dhondt (Cancer Research Institute Ghent)
Dolores Di Vizio (Cedars-Sinai Medical Center)
Lothar C Dieterich (ETH Zurich)
Vincenza Dolo (University of L’Aquila)
Ana Paula Dominguez Rubio (Universidad de Buenos Aires)
Massimo Dominici (TPM of Mirandola)
Mauricio R Dourado (University of Campinas, Piracicaba Dental School)
Tom AP Driedonks (Utrecht University)
Filipe V Duarte (Exogenus Therapeutics)
Heather M Duncan (McGill University)
Ramon M Eichenberger (James Cook University)
Karin Ekström (University of Gothenburg, Institute of Clinical Sciences at Sahlgrenska Academy)
Samir EL Andaloussi (Evox Therapeutics Limited)
Celine Elie-Caille (UBFC, CNRS, ENSMM, UTBM)
Uta Erdbrügger (University of Virginia Health System)
Juan M Falcón-Pérez (CIC bioGUNE, CIBERehd)
Farah Fatima (University of São Paulo, Ribeirão Preto Medical School)
Jason E Fish (Toronto General Hospital Research Institute, University Health Network)
Miguel Flores-Bellver (University of Colorado, School of Medicine)
András Försönits (Semmelweis University)
Annie Frelet-Barrand (UBFC, CNRS, ENSMM, UTBM)
Fabia Fricke (German Cancer Research Center (DKFZ), Clinical Cooperation Unit Applied Tumor Biology)
Gregor Fuhrmann (Helmholtz-Centre for Infection Research)
Susanne Gabrielsson (Karolinska Institute)
Ana Gámez-Valero (Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, REMAR-IVECAT Group)
Chris Gardiner (University College London)
Kathrin Gärtner (Helmholtz Center Munich German Research Center for Environmental Health, Research Unit Gene Vectors)
Raphael Gaudin (INSERM U1110)
Yong Song Gho (POSTECH (Pohang University of Science and Technology))
Bernd Giebel (University Hospital Essen, University Duisburg-Essen, Institute for Transfusion Medicine)
Caroline Gilbert (Université Laval, Centre de Recherche du CHU de Québec)
Mario Gimona (Paracelsus Medical University, GMP Unit)
Ilaria Giusti (University of L’Aquila)
Deborah CI Goberdhan (University of Oxford)
André Görgens (Evox Therapeutics Limited)
Sharon M Gorski (Canada’s Michael Smith Genome Sciences Centre)
David W Greening (La Trobe University, La Trobe Institute for Molecular Science)
Julia Christina Gross (University Medical Center Göttingen)
Alice Gualerzi (IRCCS Fondazione Don Carlo Gnocchi)
Gopal N Gupta (Loyola University Chicago)
Dakota Gustafson (University of Toronto)
Aase Handberg (Aalborg University Hospital)
Reka A Haraszti (University of Massachusetts Medical School, RNA Therapeutics Institute)
Paul Harrison (University of Birmingham)
Hargita Hegyesi (Semmelweis University)
An Hendrix (Cancer Research Institute Ghent)
Andrew F Hill (La Trobe University, La Trobe Institute for Molecular Science)
Fred H Hochberg (Scintillon Institute)
Karl F Hoffmann (Aberystwyth University)
Beth Holder (Imperial College London)
Harry Holthofer (University Clinic Eppendorf)
Baharak Hosseinkhani (Hasselt University, Biomedical Research Institute (BIOMED))
Guoku Hu (University of Nebraska Medical Center)
Yiyao Huang (Nanfang Hospital, Southern Medical University)
Veronica Huber (Unit of Immunotherapy of Human Tumors)
Stuart Hunt (The University of Sheffield)
Ahmed Gamal-Eldin Ibrahim (Cedars-Sinai Medical Center, Smidt Heart Institute)
Tsuneya Ikezu (Boston University School of Medicine)
Jameel M Inal (University of Hertfordshire, School of Life and Medical Sciences, Biosciences Research Group)
Mustafa Isin (Istanbul University Oncology Institute)
Alena Ivanova (German Cancer Research Center (DKFZ))
Hannah K Jackson (The University of Nottingham)
Soren Jacobsen (Section 4242 - Rigshospitalet)
Steven M Jay (University of Maryland)
Muthuvel Jayachandran (Mayo Clinic)
Guido Jenster (Department of Urology)
Lanzhou Jiang (La Trobe University, La Trobe Institute for Molecular Science)
Suzanne M Johnson (University of Manchester, Division of Cancer Sciences, Manchester Cancer Research Centre)
Jennifer C Jones (National Institutes of Health, National Cancer Institute, Center for Cancer Research)
Ambrose Jong (Children’s Hospital of Los Angeles)
Tijana Jovanovic-Talisman (City of Hope Comprehensive Cancer Center, Beckman Research Institute)
Stephanie Jung (German Research Center for Environmental Health)
Raghu Kalluri (University of Texas MD Anderson Cancer Center)
Shin-ichi Kano (The Johns Hopkins University School of Medicine)
Sukhbir Kaur (National Institutes of Health, National Cancer Institute, Center for Cancer Research, Laboratory of Pathology)
Yumi Kawamura (National Cancer Center Research Institute)
Evan T Keller (University of Michigan, Biointerfaces Institute)
Delaram Khamari (Semmelweis University)
Elena Khomyakova (École normale supérieure)
Anastasia Khvorova (University of Massachusetts Medical School, RNA Therapeutics Institute)
Peter Kierulf (Blood Cell Research Group)
Kwang Pyo Kim (Kyung Hee University)
Thomas Kislinger (Princess Margaret Cancer Centre, University Health Network)
Mikael Klingeborn (Duke University)
David J Klinke (West Virginia University)
Miroslaw Kornek (German Armed Forces Central Hospital)
Maja M Kosanović (University of Belgrade, Institute for the Application of Nuclear Energy, INEP)
Árpád Ferenc Kovács (Semmelweis University)
Eva-Maria Krämer-Albers (University of Mainz, Institute of Developmental Biology and Neurobiology)
Susanne Krasemann (University Medical Center Hamburg-Eppendorf, Institute of Neuropathology)
Mirja Krause (Hudson Institute of Medical Research)
Igor V Kurochkin (Sysmex Co)
Gina D Kusuma (Hudson Institute of Medical Research)
Sören Kuypers (Hasselt University, Biomedical Research Institute (BIOMED))
Saara Laitinen (Research and Development)
Scott M Langevin (Cincinnati Cancer Center)
Lucia R Languino (Thomas Jefferson University, Sidney Kimmel Medical School)
Joanne Lannigan (University of Virginia, Flow Cytometry Core)
Cecilia Lässer (University of Gothenburg, Institute of Medicine at Sahlgrenska Academy, Krefting Research Centre)
Louise C Laurent (University of California, San Diego)
Gregory Lavieu (Institut Curie, INSERM U932, PSL Research University)
Elisa Lázaro-Ibáñez (AstraZeneca, Discovery Sciences)
Soazig Le Lay (INSERM U1063, Université d’Angers, CHU d’Angers)
Myung-Shin Lee (Eulji University)
Yi Xin Fiona Lee (Genome Institute of Singapore, A*STAR)
Debora S Lemos (Federal University of Paraná)
Metka Lenassi (University of Ljubljana)
Aleksandra Leszczynska (University of California, San Diego)
Isaac TS Li (University of British Columbia Okanagan)
Ke Liao (University of Nebraska Medical Center)
Sten F Libregts (University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital)
Erzsebet Ligeti (Semmelweis University)
Rebecca Lim (Hudson Institute of Medical Research)
Sai Kiang Lim (Institute of Medical Biology (IMB), Agency for Science and Technology (A*STAR))
Aija Linē (Latvian Biomedical Research and Study Centre)
Karen Linnemannstöns (University Medical Center Göttingen)
Alicia Llorente (Oslo University Hospital-The Norwegian Radium Hospital, Institute for Cancer Research)
Catherine A Lombard (Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC))
Magdalena J Lorenowicz (Utrecht University, University Medical Center Utrecht, Center for Molecular Medicine & Regenerative Medicine Center)
Ákos M Lörincz (Semmelweis University)
Jan Lötvall (University of Gothenburg, Institute of Medicine at Sahlgrenska Academy, Krefting Research Centre)
Jason Lovett (Stellenbosch University)
Michelle C Lowry (Trinity College Dublin, School of Pharmacy and Pharmaceutical Sciences, Panoz Institute & Trinity Biomedical Sciences Institute)
Xavier Loyer (INSERM UMR-S 970, Paris Cardiovascular Research Center)
Quan Lu (Harvard University)
Barbara Lukomska (Mossakowski Medical Research Centre)
Taral R Lunavat (University of Bergen)
Sybren LN Maas (Utrecht University, University Medical Center Utrecht)
Harmeet Malhi (Mayo Clinic)
Antonio Marcilla (Universitat de València)
Jacopo Mariani (Università degli Studi di Milano)
Javier Mariscal (Cedars-Sinai Medical Center)
Elena S Martens-Uzunova (Department of Urology)
Lorena Martin-Jaular (Institut Curie, INSERM U932, PSL Research University)
M Carmen Martinez (INSERM U1063, Université d’Angers, CHU d’Angers)
Vilma Regina Martins (A.C.Camargo Cancer Center)
Mathilde Mathieu (Institut Curie, INSERM U932, PSL Research University)
Suresh Mathivanan (La Trobe University, La Trobe Institute for Molecular Science)
Marco Maugeri (University of Gothenburg, Sahlgrenska Academy)
Lynda K McGinnis (University of Southern California)
Mark J McVey (SickKids Hospital)
David G Meckes (Florida State University College of Medicine)
Katie L Meehan (University of Western Australia)
Inge Mertens (University of Antwerp, Centre for Proteomics)
Valentina R Minciacchi (Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy)
Andreas Möller (QIMR Berghofer Medical Research Institute)
Malene Møller Jørgensen (Aalborg University Hospital)
Aizea Morales-Kastresana (National Institutes of Health, National Cancer Institute, Center for Cancer Research)
Jess Morhayim (Erasmus MC)
François Mullier (Namur Thrombosis and Hemostasis Center (NTHC), NARILIS)
Maurizio Muraca (University of Padova)
Luca Musante (University of Virginia Health System)
Veronika Mussack (Technical University of Munich, TUM School of Life Sciences Weihenstephan)
Dillon C Muth (The Johns Hopkins University School of Medicine)
Kathryn H Myburgh (Stellenbosch University)
Tanbir Najrana (Brown University, Women and Infants Hospital)
Muhammad Nawaz (University of Gothenburg, Sahlgrenska Academy)
Irina Nazarenko (Partner Site Freiburg and German Cancer Research Center (DKFZ))
Peter Nejsum (Aarhus University)
Christian Neri (Sorbonne Université, Centre National de la Recherche Scientifique, Research Unit Biology of Adaptation and Aging (B2A))
Tommaso Neri (University of Pisa)
Rienk Nieuwland (Academic Medical Centre of the University of Amsterdam)
Leonardo Nimrichter (Universidade Federal do Rio de Janeiro, Instituto de Microbiologia)
John P Nolan (Scintillon Institute)
Esther NM Nolte-’t Hoen (Utrecht University)
Nicole Noren Hooten (National Institutes of Health, National Institute on Aging)
Lorraine O’Driscoll (Trinity College Dublin, School of Pharmacy and Pharmaceutical Sciences, Panoz Institute & Trinity Biomedical Sciences Institute)
Tina O’Grady (University of Liège, GIGA-R(MBD))
Ana O’Loghlen (Queen Mary University of London, Blizard Institute, Epigenetics & Cellular Senescence Group)
Takahiro Ochiya (National Cancer Center Research Institute)
Martin Olivier (McGill University)
Alberto Ortiz (IIS-Fundacion Jimenez Diaz-UAM)
Luis A Ortiz (Graduate School of Public Health at the University of Pittsburgh)
Xabier Osteikoetxea (AstraZeneca, Discovery Sciences)
Ole Østergaard (Statens Serum Institut)
Matias Ostrowski (University of Buenos Aires, Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS))
Jaesung Park (POSTECH (Pohang University of Science and Technology))
D. Michiel Pegtel (Amsterdam University Medical Centers)
Hector Peinado (Spanish National Cancer Research Center (CNIO), Molecular Oncology Programme, Microenvironment and Metastasis Laboratory)
Francesca Perut (IRCCS - Istituto Ortopedico Rizzoli)
Michael W Pfaffl (Technical University of Munich, TUM School of Life Sciences Weihenstephan)
Donald G Phinney (The Scripps Research Institute-Scripps Florida)
Bartijn CH Pieters (Radboud University Medical Center)
Ryan C Pink (Oxford Brookes University)
David S Pisetsky (Duke University Medical Center)
Elke Pogge von Strandmann (Philipps University Marburg)
Iva Polakovicova (Pontificia Universidad Católica de Chile, Advanced Center for Chronic Diseases (ACCDiS))
Ivan KH Poon (La Trobe University, La Trobe Institute for Molecular Science)
Bonita H Powell (The Johns Hopkins University School of Medicine)
Ilaria Prada (CNR Institute of Neuroscience)
Lynn Pulliam (University of California)
Peter Quesenberry (The Warren Alpert Medical School of Brown University)
Annalisa Radeghieri (CSGI - Research Center for Colloids and Nanoscience)
Robert L Raffai (Department of Veterans Affairs)
Stefania Raimondo (University of Palermo)
Janusz Rak (McGill University)
Marcel I Ramirez (Instituto Oswaldo Cruz)
Graça Raposo (Institut Curie, CNRS UMR144, PSL Research University)
Morsi S Rayyan (University of Michigan Medical School)
Neta Regev-Rudzki (Weizmann Institute of Science)
Franz L Ricklefs (University Medical Center Hamburg-Eppendorf)
Paul D Robbins (University of Minnesota Medical School, Institute on the Biology of Aging and Metabolism)
David D Roberts (National Institutes of Health, National Cancer Institute, Center for Cancer Research, Laboratory of Pathology)
Silvia C Rodrigues (CNC)
Eva Rohde (Paracelsus Medical University)
Sophie Rome (University of Lyon)
Kasper MA Rouschop (Maastricht University, GROW)
Aurelia Rughetti (Sapienza University of Rome)
Ashley E Russell (West Virginia University)
Paula Saá (American Red Cross, Scientific Affairs)
Susmita Sahoo (Icahn School of Medicine at Mount Sinai)
Edison Salas-Huenuleo (Advanced Center for Chronic Diseases)
Catherine Sánchez (Extracellular Vesicles in Personalized Medicine Group)
Julie A Saugstad (Oregon Health & Science University)
Meike J Saul (Technische Universität Darmstadt)
Raymond M Schiffelers (University Medical Center Utrecht, Laboratory for Clinical Chemistry & Hematology)
Raphael Schneider (University of Toronto)
Tine Hiorth Schøyen (The Johns Hopkins University School of Medicine)
Aaron Scott (University of Bristol)
Eriomina Shahaj (Unit of Immunotherapy of Human Tumors)
Shivani Sharma (University of California, Los Angeles, California NanoSystems Institute)
Olga Shatnyeva (AstraZeneca, Discovery Sciences)
Faezeh Shekari (Royan Institute for Stem Cell Biology and Technology, ACECR, Cell Science Research Center)
Ganesh Vilas Shelke (Sahlgrenska Cancer Center)
Ashok K Shetty (Research Service, Olin E. Teague Veterans’ Medical Center)
Kiyotaka Shiba (Cancer Institute of JFCR)
Pia R-M Siljander (University of Helsinki)
Andreia M Silva (INEB - Instituto de Engenharia Biomédica)
Agata Skowronek (Maria Sklodowska-Curie Institute - Oncology Center, Gliwice Branch)
Orman L Snyder (Kansas State University)
Rodrigo Pedro Soares (René Rachou Institute/FIOCRUZ)
Barbara W Sódar (Semmelweis University)
Carolina Soekmadji (QIMR Berghofer Medical Research Institute)
Javier Sotillo (James Cook University)
Philip D Stahl (Washington University)
Willem Stoorvogel (Utrecht University)
Shannon L Stott (Harvard Medical School)
Erwin F Strasser (FAU Erlangen-Nuremberg)
Simon Swift (University of Auckland)
Hidetoshi Tahara (Hiroshima University, Institute of Biomedical & Health Sciences)
Muneesh Tewari (University of Michigan, Biointerfaces Institute)
Kate Timms (University of Manchester)
Swasti Tiwari (Georgetown University)
Rochelle Tixeira (La Trobe University, La Trobe Institute for Molecular Science)
Mercedes Tkach (Institut Curie, INSERM U932, PSL Research University)
Wei Seong Toh (National University of Singapore)
Richard Tomasini (INSERM U1068, Aix Marseille University, CNRS UMR7258)
Ana Claudia Torrecilhas (UNIFESP)
Juan Pablo Tosar (Institut Pasteur de Montevideo, Functional Genomics Unit)
Vasilis Toxavidis (Beth Israel Deaconess Medical Center)
Lorena Urbanelli (University of Perugia)
Pieter Vader (University Medical Center Utrecht, Laboratory for Clinical Chemistry & Hematology)
Bas WM van Balkom (University Medical Center Utrecht)
Susanne G van der Grein (Utrecht University)
Jan Van Deun (Cancer Research Institute Ghent)
Martijn JC van Herwijnen (Utrecht University)
Kendall Van Keuren-Jensen (TGen)
Guillaume van Niel (Center for Psychiatry and Neuroscience, INSERM U894)
Martin E van Royen (Erasmus MC, Erasmus Optical Imaging Centre)
Andre J van Wijnen (Mayo Clinic)
M Helena Vasconcelos (IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto)
Ivan J Vechetti (University of Kentucky, College of Medicine)
Tiago D Veit (Universidade Federal do Rio Grande do Sul, Instituto de Ciências Básicas da Saúde)
Laura J Vella (The Florey Institute of Neuroscience and Mental Health)
Émilie Velot (UMR 7365 CNRS-Université de Lorraine)
Frederik J Verweij (Center for Psychiatry and Neuroscience, INSERM U894)
Beate Vestad (Oslo University Hospital Rikshospitalet, Research Institute of Internal Medicine)
Jose L Viñas (Kidney Research Centre)
Tamás Visnovitz (Semmelweis University)
Krisztina V Vukman (Semmelweis University)
Jessica Wahlgren (University of Gothenburg, The Sahlgrenska Academy, Institute of Neuroscience and Physiology)
Dionysios C Watson (Case Western Reserve University)
Marca HM Wauben (Utrecht University)
Alissa Weaver (Vanderbilt University School of Medicine)
Jason P Webber (Cardiff University)
Viktoria Weber (Danube University Krems)
Ann M Wehman (University of Würzburg, Rudolf Virchow Center)
Daniel J Weiss (The University of Vermont Medical Center)
Joshua A Welsh (National Institutes of Health, National Cancer Institute, Center for Cancer Research)
Sebastian Wendt (University Hospital RWTH Aachen)
Asa M Wheelock (Karolinska Institute)
Zoltán Wiener (Semmelweis University)
Leonie Witte (University Medical Center Göttingen)
Joy Wolfram (Chinese Academy of Sciences)
Angeliki Xagorari (George Papanicolaou Hospital)
Patricia Xander (Universidade Federal de São Paulo Campus Diadema)
Jing Xu (Canada’s Michael Smith Genome Sciences Centre)
Xiaomei Yan (Xiamen University)
María Yáñez-Mó (Instituto de Investigación Sanitaria la Princesa (IIS-IP))
Hang Yin (Tsinghua University)
Yuana Yuana (Technical University Eindhoven)
Valentina Zappulli (University of Padova)
Jana Zarubova (Institute of Physiology CAS)
Vytautas Žėkas (Vilnius University)
Jian-ye Zhang (Guangzhou Medical University)
Zezhou Zhao (The Johns Hopkins University School of Medicine)
Lei Zheng (Nanfang Hospital, Southern Medical University)
Alexander R Zheutlin (University of Michigan Medical School)
Antje M Zickler (Karolinska Institute, Clinical Research Center, Unit for Molecular Cell and Gene Therapy Science)
Pascale Zimmermann (Aix-Marseille Université, Institut Paoli-Calmettes, INSERM U1068, CNRS UMR7258, Centre de Recherche en Cancérologie de Marseille)
Angela M Zivkovic (University of California, Davis)
Davide Zocco (Exosomics Siena SpA)
Ewa K Zuba-Surma (Jagiellonian University)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 12 weeks

 

Abstract | Full Text

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.