Intraglandular mesenchymal stem cell treatment induces changes in the salivary proteome of irradiated patients

Charlotte Duch Lynggaard; Rosa Jersie-Christensen; Morten Juhl; Siri Beier Jensen; Christian Grønhøj; Jacob Melchiors; Søren Jacobsen; Michael Møller-Hansen; Mikkel Herly; Annette Ekblond; Jens Kastrup; Anne Fischer-Nielsen; Daniel Belstrøm; Christian von Buchwald

doi:10.1038/s43856-022-00223-3

Communications Medicine (Dec 2022)

Intraglandular mesenchymal stem cell treatment induces changes in the salivary proteome of irradiated patients

Charlotte Duch Lynggaard,
Rosa Jersie-Christensen,
Morten Juhl,
Siri Beier Jensen,
Christian Grønhøj,
Jacob Melchiors,
Søren Jacobsen,
Michael Møller-Hansen,
Mikkel Herly,
Annette Ekblond,
Jens Kastrup,
Anne Fischer-Nielsen,
Daniel Belstrøm,
Christian von Buchwald

Affiliations

Charlotte Duch Lynggaard: Department of Otolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital
Rosa Jersie-Christensen: Department of Science and Environment, Roskilde University
Morten Juhl: Cardiology Stem Cell Centre, Rigshospitalet, Copenhagen University Hospital
Siri Beier Jensen: Department of Dentistry and Oral Health, Aarhus University
Christian Grønhøj: Department of Otolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital
Jacob Melchiors: Department of Otolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital
Søren Jacobsen: Department of Clinical Medicine, Copenhagen University
Michael Møller-Hansen: Department of Ophthalmology, Rigshospitalet, Copenhagen University Hospital
Mikkel Herly: Department of Plastic Surgery and Burns Treatment, Rigshospitalet, Copenhagen University Hospital
Annette Ekblond: Cardiology Stem Cell Centre, Rigshospitalet, Copenhagen University Hospital
Jens Kastrup: Cardiology Stem Cell Centre, Rigshospitalet, Copenhagen University Hospital
Anne Fischer-Nielsen: Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital
Daniel Belstrøm: Department of Odontology, Section for Clinical Oral Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen
Christian von Buchwald: Department of Otolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital

DOI: https://doi.org/10.1038/s43856-022-00223-3
Journal volume & issue: Vol. 2, no. 1
pp. 1 – 12

Abstract

Read online

Lynggaard et al. profile the salivary proteome and metaproteome in patients with head and neck cancer who have received radiation therapy and an intraglandular mesenchymal stem cell (MSC) treatment for radiation-induced xerostomia and in healthy controls. MSC therapy impacts the composition of the salivary proteome in the longer-term.

Published in Communications Medicine

ISSN: 2730-664X (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.nature.com/commsmed/

About the journal