iScience (Mar 2023)

Adoptive immune transfer from donors offers Anti-HBV protection to HBsAb-negative patients after Allo-HSCT

  • Jinhua Ren,
  • QiaoXian Lin,
  • Qi Chen,
  • Jingjing Xu,
  • Dabin Chen,
  • Renli Chen,
  • Kangni Lin,
  • Haojie Zhu,
  • Chenjing Ye,
  • Xiaofeng Luo,
  • Shaozhen Chen,
  • Hui Kong,
  • Qiong Lin,
  • Nan Li,
  • Xu Lin,
  • Zhizhe Chen,
  • Jianda Hu,
  • Ting Yang

Journal volume & issue
Vol. 26, no. 3
p. 106290

Abstract

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Summary: Adoptive transfer of hepatitis B virus (HBV) immunity may occur following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, we investigated the adoptive transfer of HBV immunity in 112 patients without HBV surface antibody (HBsAb) (HBsAb-) at the time of their first allo-HSCT. After allo-HSCT, HBV-DNA(87.5%) and HBsAg(11.1%%)cleared in HBsAg+ patients. All HBsAg- patients acquired HBsAb immediately. Nevertheless, HBsAb titers subsequently declined, and 39/67 (58.2%) patients lost HBsAb during follow-up. The 5-year overall survival (OS) was better in patients who lost HBsAb. Multivariate analysis showed that the independent risk factors for OS were lack of cytomegalovirus (CMV) clearance, acute graft-versus-host disease (aGVHD), and no HBsAb loss. Overall, adoptive immune transfer offers anti-HBV protection to patients without HBsAb, as they acquire HBsAb and clear HBV-DNA and HBsAg, while HBsAb loss after allo-HSCT predicts better survival.

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