Nature Communications (Apr 2023)
Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage
- Rita Rosado-Ramos,
- Gonçalo M. Poças,
- Daniela Marques,
- Alexandre Foito,
- David M. Sevillano,
- Mafalda Lopes-da-Silva,
- Luís G. Gonçalves,
- Regina Menezes,
- Marcel Ottens,
- Derek Stewart,
- Alain Ibáñez de Opakua,
- Markus Zweckstetter,
- Miguel C. Seabra,
- César S. Mendes,
- Tiago Fleming Outeiro,
- Pedro M. Domingos,
- Cláudia N. Santos
Affiliations
- Rita Rosado-Ramos
- iBET, Instituto de Biologia Experimental e Tecnológica
- Gonçalo M. Poças
- Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA)
- Daniela Marques
- iNOVA4Health, NOVA Medical School Faculdade de Ciências Médicas, NMS FCM, Universidade Nova de Lisboa
- Alexandre Foito
- Environmental and Biochemical Sciences, The James Hutton Institute
- David M. Sevillano
- Department of Biotechnology, Delft University of Technology
- Mafalda Lopes-da-Silva
- iNOVA4Health, NOVA Medical School Faculdade de Ciências Médicas, NMS FCM, Universidade Nova de Lisboa
- Luís G. Gonçalves
- Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA)
- Regina Menezes
- iBET, Instituto de Biologia Experimental e Tecnológica
- Marcel Ottens
- Department of Biotechnology, Delft University of Technology
- Derek Stewart
- Environmental and Biochemical Sciences, The James Hutton Institute
- Alain Ibáñez de Opakua
- German Center for Neurodegenerative Diseases (DZNE)
- Markus Zweckstetter
- German Center for Neurodegenerative Diseases (DZNE)
- Miguel C. Seabra
- iNOVA4Health, NOVA Medical School Faculdade de Ciências Médicas, NMS FCM, Universidade Nova de Lisboa
- César S. Mendes
- iNOVA4Health, NOVA Medical School Faculdade de Ciências Médicas, NMS FCM, Universidade Nova de Lisboa
- Tiago Fleming Outeiro
- German Center for Neurodegenerative Diseases (DZNE)
- Pedro M. Domingos
- Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA)
- Cláudia N. Santos
- iBET, Instituto de Biologia Experimental e Tecnológica
- DOI
- https://doi.org/10.1038/s41467-023-37561-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 21
Abstract
In this work, the authors identify Genipin as a small iridoid able to prevent alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.
