Nature Communications (Nov 2018)

Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems

  • Qingxin Yao,
  • Feng Lin,
  • Xinyuan Fan,
  • Yanpu Wang,
  • Ye Liu,
  • Zhaofei Liu,
  • Xingyu Jiang,
  • Peng R. Chen,
  • Yuan Gao

DOI
https://doi.org/10.1038/s41467-018-07490-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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The side effects of cancer drugs limit their utility. Here, the authors developed a method in which an inactive (prodrug) version of the cancer drug doxorubicin enters tumour cells and then gets activated inside the cells upon a trigger facilitated by enzyme-instructed supramolecular self-assembly.