Association of allele variants of receptor gene of androgens (by the number of CAG-repeats) with androgen dependent hormonal metabolic indices of the organism

V. V. Korpachev; S. V. Melnychenko; R. G. Lukashova

doi:10.15407/ubj87.02.026

The Ukrainian Biochemical Journal (Apr 2015)

Association of allele variants of receptor gene of androgens (by the number of CAG-repeats) with androgen dependent hormonal metabolic indices of the organism

V. V. Korpachev,
S. V. Melnychenko,
R. G. Lukashova

Affiliations

V. V. Korpachev: State Institution V. Р. Komisarenko Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv
S. V. Melnychenko: State Institution V. Р. Komisarenko Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv
R. G. Lukashova: State Institution V. Р. Komisarenko Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv

DOI: https://doi.org/10.15407/ubj87.02.026
Journal volume & issue: Vol. 87, no. 2
pp. 26 – 40

Abstract

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This review discusses up-to-date conceptions concerning an association of androgen receptor gene (AR) allele (by the number of CAG-repeats) variations with the change of the receptor activity in humans. Different contradictory experiment results concerning the AR function dependence on the number of CAG-repeats have been analyzed. The authors discuss this problem paying mostly their attention to the interrelation between the number of CAG-repeats and indicators of glucose and lipid metabolism in males and females.

Published in The Ukrainian Biochemical Journal

ISSN: 2409-4943 (Print); 2413-5003 (Online)
Publisher: National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
Country of publisher: Ukraine
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry; Medicine; Science: Biology (General)
Website: http://ukrbiochemjournal.org/

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