Nature Communications (Jun 2019)
Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease
- Caroline Gluck,
- Chengxiang Qiu,
- Sang Youb Han,
- Matthew Palmer,
- Jihwan Park,
- Yi-An Ko,
- Yuting Guan,
- Xin Sheng,
- Robert L. Hanson,
- Jing Huang,
- Yong Chen,
- Ae Seo Deok Park,
- Maria Concepcion Izquierdo,
- Ioannis Mantzaris,
- Amit Verma,
- James Pullman,
- Hongzhe Li,
- Katalin Susztak
Affiliations
- Caroline Gluck
- Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania
- Chengxiang Qiu
- Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania
- Sang Youb Han
- Division of Nephrology, Department of Internal Medicine, Inje University College of Medicine
- Matthew Palmer
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Jihwan Park
- Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania
- Yi-An Ko
- Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania
- Yuting Guan
- Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania
- Xin Sheng
- Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania
- Robert L. Hanson
- Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases
- Jing Huang
- Department of Biostatistics, Epidemiology, and Informatics, Center for Clinical Epidemiology and Biostatistics, School of Medicine, University of Pennsylvania Perelman
- Yong Chen
- Department of Biostatistics, Epidemiology, and Informatics, Center for Clinical Epidemiology and Biostatistics, School of Medicine, University of Pennsylvania Perelman
- Ae Seo Deok Park
- Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania
- Maria Concepcion Izquierdo
- Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania
- Ioannis Mantzaris
- Department of Medicine, Albert Einstein College of Medicine
- Amit Verma
- Department of Medicine, Albert Einstein College of Medicine
- James Pullman
- Department of Pathology Montefiore Medical Center
- Hongzhe Li
- Department of Biostatistics, Epidemiology, and Informatics, Center for Clinical Epidemiology and Biostatistics, School of Medicine, University of Pennsylvania Perelman
- Katalin Susztak
- Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania
- DOI
- https://doi.org/10.1038/s41467-019-10378-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Patients with diabetes commonly develop diabetic kidney disease (DKD). Here Gluck et al. identify a set of probes differentially methylated in renal samples from patients with DKD, and find that inclusion of these methylation probes improves current prediction models of renal function decline.
