Pancreatic neuroendocrine tumor with solitary splenic metastasis and synchronous renal cell carcinoma: A rare case report

Michael Teklehaimanot Abera, MD; Yacob Sheiferawe Seman, MD; Hidaya Yahya Mohammed, MD; Fadil Nuredin Abrar, MD; Admassu Melaku Mikru, MD; Mahlet Kifle Mersha, MD

Radiology Case Reports (Jul 2024)

Pancreatic neuroendocrine tumor with solitary splenic metastasis and synchronous renal cell carcinoma: A rare case report

Michael Teklehaimanot Abera, MD,
Yacob Sheiferawe Seman, MD,
Hidaya Yahya Mohammed, MD,
Fadil Nuredin Abrar, MD,
Admassu Melaku Mikru, MD,
Mahlet Kifle Mersha, MD

Affiliations

Michael Teklehaimanot Abera, MD: Addis Ababa University, College of Health Sciences, Department of Radiology, Addis Ababa, Ethiopia; Corresponding author.
Yacob Sheiferawe Seman, MD: Addis Ababa University, College of Health Sciences, Department of Urology, Addis Ababa, Ethiopia
Hidaya Yahya Mohammed, MD: Addis Ababa University, College of Health Sciences, Department of Pathology, Addis Ababa, Ethiopia
Fadil Nuredin Abrar, MD: Addis Ababa University, College of Health Sciences, Department of Pathology, Addis Ababa, Ethiopia
Admassu Melaku Mikru, MD: Addis Ababa University, College of Health Sciences, Department of Urology, Addis Ababa, Ethiopia
Mahlet Kifle Mersha, MD: Addis Ababa University, College of Health Sciences, Department of Radiology, Addis Ababa, Ethiopia

Journal volume & issue: Vol. 19, no. 7
pp. 2760 – 2766

Abstract

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Synchronous pancreatic neuroendocrine tumors and renal cell cancer are extremely rare. Von-Hipple-Landau syndrome is a major association. A 43-year-old male patient with left upper quadrant pain and significant weight loss was diagnosed with a synchronous pancreatic tail neuroendocrine tumor with solitary splenic metastasis and a clear-cell renal cell carcinoma of the left kidney. Sonography and a computed tomography scan of the abdomen showed a complex exophytic left renal mass and a necrotic lesion limited to the spleen. Although not apparent on preoperative imaging, distal pancreatic mass was also discovered intraoperatively. Subsequently, left radical nephrectomy, splenectomy, and distal pancreatectomy were performed, and the synchronous primaries and splenic metastasis were confirmed histopathologically. This case is unique in that it demonstrates multiple extremely rare events occurring simultaneously, namely pancreatic and kidney primaries, as well as solitary splenic metastasis.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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