Correlation Between Ki67 Expression and 18F-FDG PET/CT SUVmax in Patient with Diffuse Large B-cell Lymphoma and Their Application in Therapeutic Effect Evaluation

YANG Ming; FENG Yanlin; LIU Dejun; YU Fengwen; HUANG Kemin; LI Wen; XIAN Weijun; LU Shengnan; WANG Ying

doi:10.3971/j.issn.1000-8578.2018.18.0652

Zhongliu Fangzhi Yanjiu (Dec 2018)

Correlation Between Ki67 Expression and 18F-FDG PET/CT SUVmax in Patient with Diffuse Large B-cell Lymphoma and Their Application in Therapeutic Effect Evaluation

YANG Ming,
FENG Yanlin,
LIU Dejun,
YU Fengwen,
HUANG Kemin,
LI Wen,
XIAN Weijun,
LU Shengnan,
WANG Ying

Affiliations

YANG Ming: Nuclear Medicine Department, The First People's Hospital of Foshan, Foshan 528000, China
FENG Yanlin: Nuclear Medicine Department, The First People's Hospital of Foshan, Foshan 528000, China
LIU Dejun: Nuclear Medicine Department, The First People's Hospital of Foshan, Foshan 528000, China
YU Fengwen: Nuclear Medicine Department, The First People's Hospital of Foshan, Foshan 528000, China
HUANG Kemin: Nuclear Medicine Department, The First People's Hospital of Foshan, Foshan 528000, China
LI Wen: Nuclear Medicine Department, The First People's Hospital of Foshan, Foshan 528000, China
XIAN Weijun: Nuclear Medicine Department, The First People's Hospital of Foshan, Foshan 528000, China
LU Shengnan: Nuclear Medicine Department, The First People's Hospital of Foshan, Foshan 528000, China
WANG Ying: Nuclear Medicine Department, The First People's Hospital of Foshan, Foshan 528000, China

DOI: https://doi.org/10.3971/j.issn.1000-8578.2018.18.0652
Journal volume & issue: Vol. 45, no. 12
pp. 1004 – 1008

Abstract

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Objective To discuss the correlation between Ki67 expression and 18F-FDG PET/CT SUVmax in patients with diffuse large B-cell lymphoma(DLBLC) and their application in the evaluation of chemotherapy effect. Methods We retrospectively analyzed 18F-FDG PET/CT images of 55 patients initially diagnosed as DLBLC in our hospital, observed the correlation between Ki67 expression and SUVmax, evaluated the chemotherapy effect by 18F-FDG PET/CT scan, and analyzed whether age, gender, SUVmax and Ki67 expression were the independent influence factors of chemotherapy effect. Results SUVmax was positively correlated with Ki67 expression (P 0.05); Age, gender, SUVmax and Ki67 were not independent influencing factors of chemotherapy effect (P > 0.05). Conclusion 18F-FDG PET/CT SUVmax could predict the proliferation and invasion of DLBCL cells, but there is no correlation between SUVmax and chemotherapy effect. Age, gender, SUVmax and Ki67 expression are not independent influencing factors of chemotherapy effect.

Published in Zhongliu Fangzhi Yanjiu

ISSN: 1000-8578 (Print)
Publisher: Magazine House of Cancer Research on Prevention and Treatment
Country of publisher: China
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.zlfzyj.com

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