Haematologica (Mar 2008)

Investigation of FDG-PET/CT imaging to guide biopsies in the detection of histological transformation of indolent lymphoma

  • Caroline Bodet-Milin,
  • Françoise Kraeber-Bodéré,
  • Philippe Moreau,
  • Loïc Campion,
  • Benoît Dupas,
  • Steven Le Gouill

DOI
https://doi.org/10.3324/haematol.12013
Journal volume & issue
Vol. 93, no. 3

Abstract

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Positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) has been successfully evaluated in the management of non-Hodgkin’s lymphoma (NHL).1–3 Histological transformation (HT) of indolent lymphoma is a dramatic event that occurs in 5–10% of the patients and carries a dismal prognosis.4,5 Previous studies prove that indolent lymphoma entities show a lower FDG uptake when compared with aggressive lymphomas.6–8 We therefore postulated that FDG-PET/CT identifies aggressive transformation sites and can guide biopsies.