Lipid-laden alveolar macrophages in induced sputum in patients with gastroesophageal reflux disease

Abstract

The aim of the study was to evaluate the diagnostic role of a lipid index of macrophages in induced sputum as a marker of aspiration of acidic gastric contents. 17 patients with the diagnosis of gastroesophageal reflux disease (GERD) and 10 healthy volunteers without any chronic digestive disorder were examined. In the group of patients with GERD, the maximal number of cells with positive reaction to lipids (31,70 ± 17,55) and maximal lipid index (45,06 ± 17,15), exceeding the control value five times, were found ( р < 0,05). The detection of lipid-laden alveolar macrophages in induced sputum can become a screenings method for diagnostics of gastroesophageal reflux. This requires the further investigations to clear up its causes.

Keywords

• гастроэзофагеальная рефлюксная болезнь
• индуцированная мокрота
• альвеолярные макрофаги
• загруженные липидами
• липидный индекс
• gastroesophageal reflux disease
• induced sputum
• lipid-laden alveolar macrophages
• lipid index