Nature Communications (Apr 2021)

Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12

  • Omar M. Khan,
  • Jorge Almagro,
  • Jessica K. Nelson,
  • Stuart Horswell,
  • Vesela Encheva,
  • Kripa S. Keyan,
  • Bruce E. Clurman,
  • Ambrosius P. Snijders,
  • Axel Behrens

DOI
https://doi.org/10.1038/s41467-021-22319-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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The tumor suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF) and itself a target for ubiquitylation. Here, the authors show that TRIP12 mediates branched K11-linked ubiquitylation of FBW7, to regulate its stability and thus abundance of a subset of SCFFBW7 substrates.