The association study of gene polymorphism of vascular endothelial growth factor with diabetic retinopathy

Abstract

AIM:To investigate the correlation of vascular endothelial factor(VEGF)I/D gene polymorphism with diabetic retinopathy(DR)in type 2 diabetes mellitus. METHODS: The 91 patients with diabetes and 30 control cases which VEGF I/D genotypes and VEGF level were determined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).RESULTS: The DD genotype frequencies were significantly higher in NPDR and PDR groups than in groups of NDR and control(PPCONCLUSION: VEGF I/D gene polymorphism is associated with the development of diabetic retinopathy; D allele is probably a susceptible gene of diabetic retinopathy.

Keywords

• vascular endothelial
• growth factor
• gene polymorphism
• diabetic retinopathy