Clonal architectures predict clinical outcome in clear cell renal cell carcinoma

Yi Huang; Jiayin Wang; Peilin Jia; Xiangchun Li; Guangsheng Pei; Changxi Wang; Xiaodong Fang; Zhongming Zhao; Zhiming Cai; Xin Yi; Song Wu; Baifeng Zhang

doi:10.1038/s41467-019-09241-7

Nature Communications (Mar 2019)

Clonal architectures predict clinical outcome in clear cell renal cell carcinoma

Yi Huang,
Jiayin Wang,
Peilin Jia,
Xiangchun Li,
Guangsheng Pei,
Changxi Wang,
Xiaodong Fang,
Zhongming Zhao,
Zhiming Cai,
Xin Yi,
Song Wu,
Baifeng Zhang

Affiliations

Yi Huang: Department of Computer Science and Technology, School of Electronic and Information Engineering, Xi’an Jiaotong University
Jiayin Wang: Department of Computer Science and Technology, School of Electronic and Information Engineering, Xi’an Jiaotong University
Peilin Jia: Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston
Xiangchun Li: Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital
Guangsheng Pei: Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston
Changxi Wang: Geneplus-Beijing
Xiaodong Fang: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Zhongming Zhao: Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston
Zhiming Cai: The Third Affiliated Hospital of Shenzhen University
Xin Yi: Geneplus-Beijing
Song Wu: The Third Affiliated Hospital of Shenzhen University
Baifeng Zhang: Geneplus-Beijing

DOI: https://doi.org/10.1038/s41467-019-09241-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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Clear cell renal cell carcinoma (ccRCC) is a urogenital cancer with a well-defined genetic landscape. Here, the authors analyse the clonal architecture of ccRCC patients from three populations, and find prognostic subtypes linked to immune infiltrates and clonal architecture.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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