CTLA4 promoter hypomethylation is a negative prognostic biomarker at initial diagnosis but predicts response and favorable outcome to anti-PD-1 based immunotherapy in clear cell renal cell carcinoma

• Dimo Dietrich,
• Lutz Trojan,
• Niklas Klümper,
• Damian J Ralser,
• Romina Zarbl,
• Glen Kristiansen,
• Marieta Toma,
• Manuel Ritter,
• Michael Hölzel,
• Jörg Ellinger,
• Markus Eckstein,
• Danijel Sikic,
• Katrin Schlack,
• Andres Jan Schrader,
• Marc Rehlinghaus,
• Michèle J Hoffmann,
• Günter Niegisch,
• Annemarie Uhlig,
• Julie Steinestel,
• Konrad Steinestel,
• Ralph M Wirtz,
• Sebastian Strieth

Affiliations

Dimo Dietrich

Center for Integrated Oncology Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Bonn, Germany

Lutz Trojan

Department of Urology, University Hospital Göttingen, Göttingen, Germany

Niklas Klümper

Institute of Experimental Oncology, University Medical Center Bonn (UKB), Bonn, Germany

Damian J Ralser

Center for Integrated Oncology Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Bonn, Germany

Romina Zarbl

Center for Integrated Oncology Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Bonn, Germany

Glen Kristiansen

Center for Integrated Oncology Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Bonn, Germany

Marieta Toma

Center for Integrated Oncology Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Bonn, Germany

Manuel Ritter

Center for Integrated Oncology Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Bonn, Germany

Michael Hölzel

Institute of Experimental Oncology, University Medical Center Bonn (UKB), Bonn, Germany

Jörg Ellinger

Center for Integrated Oncology Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Bonn, Germany

Markus Eckstein

Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany

Danijel Sikic

Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany

Katrin Schlack

Department of Urology, University Hospital Münster, Münster, Germany

Andres Jan Schrader

Department of Urology, University Hospital Münster, Münster, Germany

Marc Rehlinghaus

Department of Urology, University Hospital Düsseldorf, Medical Faculty, Düsseldorf, Germany

Michèle J Hoffmann

Department of Urology, University Hospital Düsseldorf, Medical Faculty, Düsseldorf, Germany

Günter Niegisch

Department of Urology, University Hospital Düsseldorf, Medical Faculty, Düsseldorf, Germany

Annemarie Uhlig

Department of Urology, University Hospital Göttingen, Göttingen, Germany

Julie Steinestel

Department of Urology, University Hospital Augsburg, Augsburg, Germany

Konrad Steinestel

Institute of Pathology and Molecular Pathology, Bundeswehrkrankenhaus Ulm, Ulm, Germany

Ralph M Wirtz

STRATIFYER Molecular Pathology GmbH, Cologne, Germany

Sebastian Strieth

Center for Integrated Oncology Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Bonn, Germany