Research progress of adaptive therapy strategy based on Darwinian dynamics in tumor therapy

Abstract

The applications of adjuvant chemotherapy and targeted drugs have greatly improved the prognosis of patients with advanced cancer, however the rapid emergence of drug resistance and the subsequent rapid progress of the disease have always been the unmet challenges in the field of cancer treatment. Adaptive therapy (AT) combined with Darwinian evolutionary dynamics is a new treatment concept different from the traditional maximum tolerated dose (MTD), which is expected to overturn the treatment paradigm of advanced cancer and achieve long-term low load tumor bearing survival. This paper reviewed the theory of AT and the important role of mathematical models in optimizing adaptive treatment strategies, then briefly described other tumor treatment strategies based on Darwinian dynamics, in order to provide new ideas for clinicians in the game with advanced cancer.

Keywords

• |tumor evolution|adaptive therapy|mathematical model|darwin|individualized treatment