Monocyte Chemoattractant Protein-1 (MCP-1), Activin-A and Clusterin in Children and Adolescents with Obesity or Type-1 Diabetes Mellitus
Eirini Kostopoulou,
Dimitra Kalavrizioti,
Panagiota Davoulou,
Evangelos Papachristou,
Xenophon Sinopidis,
Sotirios Fouzas,
Theodore Dassios,
Despoina Gkentzi,
Stavroula Ioanna Kyriakou,
Ageliki Karatza,
Gabriel Dimitriou,
Dimitrios Goumenos,
Bessie E. Spiliotis,
Panagiotis Plotas,
Marios Papasotiriou
Affiliations
Eirini Kostopoulou
Division of Pediatric Endocrinology, Department of Pediatrics, University Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, Greece
Dimitra Kalavrizioti
Department of Nephrology and Kidney Transplantation, University Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, Greece
Panagiota Davoulou
Department of Nephrology and Kidney Transplantation, University Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, Greece
Evangelos Papachristou
Department of Nephrology and Kidney Transplantation, University Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, Greece
Xenophon Sinopidis
Department of Pediatric Surgery, University Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, Greece
Sotirios Fouzas
Department of Pediatrics, University Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, Greece
Theodore Dassios
Department of Pediatrics, University Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, Greece
Despoina Gkentzi
Department of Pediatrics, University Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, Greece
Stavroula Ioanna Kyriakou
Department of Pediatric Surgery, University Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, Greece
Ageliki Karatza
Department of Pediatrics, University Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, Greece
Gabriel Dimitriou
Department of Pediatrics, University Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, Greece
Dimitrios Goumenos
Department of Nephrology and Kidney Transplantation, University Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, Greece
Bessie E. Spiliotis
Division of Pediatric Endocrinology, Department of Pediatrics, University Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, Greece
Panagiotis Plotas
Department of Speech and Language Therapy, School of Health Rehabilitation Sciences, University of Patras, 26504 Patras, Greece
Marios Papasotiriou
Department of Nephrology and Kidney Transplantation, University Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, Greece
Inflammation plays a crucial role in diabetes and obesity through macrophage activation. Macrophage chemoattractant protein-1 (MCP-1), activin-A, and clusterin are chemokines with known roles in diabetes and obesity. The aim of this study is to investigate their possible diagnostic and/or early prognostic values in children and adolescents with obesity and type-1 diabetes mellitus (T1DM). Methods: We obtained serum samples from children and adolescents with a history of T1DM or obesity, in order to measure and compare MCP-1, activin-A, and clusterin concentrations. Results: Forty-three subjects were included in each of the three groups (controls, T1DM, and obesity). MCP-1 values were positively correlated to BMI z-score. Activin-A was increased in children with obesity compared to the control group. A trend for higher values was detected in children with T1DM. MCP-1 and activin-A levels were positively correlated. Clusterin levels showed a trend towards lower values in children with T1DM or obesity compared to the control group and were negatively correlated to renal function. Conclusions: The inflammation markers MCP-1, activin-A, and clusterin are not altered in children with T1DM. Conversely, obesity in children is positively correlated to serum MCP-1 values and characterized by higher activin-A levels, which may reflect an already established systematic inflammation with obesity since childhood.
